API | abt-869

abt-869 Report issue

Small molecule Experimental

AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

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Chemistry

SMILES: Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)c3cccc4[nH]nc(N)c34)c1
InChIKey: MPVGZUGXCQEXTM-UHFFFAOYSA-N
Mol. Mass: 375.41
ALogP: 4.9 Partition coefficient
ChEMBL Molecule:
linifanib

More Chemistry

Pharmacology

Mechanisms of Action:
- Macrophage colony-stimulating factor 1 receptor (Homo sapiens) ^UniProt
- Platelet-derived growth factor receptor alpha (Homo sapiens) ^UniProt
- Platelet-derived growth factor receptor beta (Homo sapiens) ^UniProt
- Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

a741439 | a 741439 | a-741439 | abt869 | abt 869 | abt-869 | al-39324 | linifanib | n-(4-(3-amino-1h-indazol-4-yl)phenyl)-n1-(2-fluoro-5-methylphenyl)urea | rg3635 | rg 3635 | rg-3635

Organizations (6)

Research & Development (6)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (18)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (18)

Adenocarcinoma (Phase 3)

Breast Neoplasms (Phase 2)

Carcinoma (Phase 3)

Carcinoma, Hepatocellular (Phase 3)

Carcinoma, Non-Small-Cell Lung (Phase 2)

Carcinoma, Renal Cell (Phase 2)

Colonic Neoplasms (Phase 2)

Colorectal Neoplasms (Phase 2)

Digestive System Diseases (Phase 3)

Digestive System Neoplasms (Phase 3)

Endometriosis (Phase 2)

Liver Diseases (Phase 3)

Liver Neoplasms (Phase 3)

Macular Degeneration (Phase 2)

Neoplasms (Phase 3)

Neoplasms by Histologic Type (Phase 3)

Neoplasms by Site (Phase 3)

Neoplasms, Glandular and Epithelial (Phase 3)

Overview

Highest Phase: Phase 3
# of Trials: 20
# of Trial Organizations: 6

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

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