Active Ingredient History

  • Now
Phenformin is a biguanide hypoglycemic agent with actions and uses similar to those of metformin. It activates AMP-activated protein kinase (AMPK) and inhibits mTORC1 signaling. Phenformin used for the treatment of diabetes. Phenformin was removed from the U.S. market 20 years ago because of a high incidence of lactic acidosis. Risk factors for the development of lactic acidosis include renal deficiency, hepatic disease, cardiac disease, and drug interaction such as cimetidine. Phenformin exerts potential anti-neoplastic action.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No
5-methoxy-2-methyl-3-indoleacetic acid | 5-methoxy-methylindoleacetic acid | dbi | (des-4-chlorobenzoyl)indomethacin | deschlorobenzoylindomethacin | dibotin s.r. | fenformin | fenformina | phenformin | phenformine | phenformin hcl | phenformin hydrochloride | phenforminum | β-phenethybiguanide


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