Active Ingredient History

  • Now
Oprozomib is an orally active second-generation proteasome inhibitor developed by Proteolix, which was acquired by Onyx Pharmaceuticals, an Amgen subsidiary, in 2009. It selectively inhibits chymotrypsin-like activity of both the constitutive proteasome (PSMB5) and immunoproteasome (LMP7).   Wikipedia

  • SMILES: COC[C@H](NC(=O)[C@H](COC)NC(=O)c1cnc(C)s1)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]3(C)CO3
  • Mol. Mass: 532.62
  • ALogP: 0.41
  • ChEMBL Molecule:
More Chemistry
onx 0912 | onx-0912 | oprozomib


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