omaveloxolone (SKYCLARYS) Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Omaveloxolone, sold under the brand name Skyclarys, is a medication used for the treatment of Friedreich's ataxia. It is taken by mouth.   Wikipedia

Chemistry

  • SMILES: CC(C)(C)C(=O)C[C@]12CCC(C)(C)C[C@H]1[C@H]3C(=O)C=C4[C@@](C)(CC[C@H]5C(C)(C)C(=O)C(=C[C@]45C)C#N)[C@]3(C)CC2
  • InChIKey: JVOADWNONSFZQK-ONLUTREGSA-N
  • Mol. Mass: 545.81
  • ALogP: 8.21
  • ChEMBL Molecule:
    omaveloxolone  
More Chemistry

Pharmacology

Alternative names

n-(11-cyano-2,2,6a,6b,9,9,12a-heptmethyl-10,14-dioxo-1,3,4,5,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydro-2h-picen-4a-yl)-2-2-difluoropropionamide | omaveloxolone | rta 408 | rta-408

Organizations (4)

Research & Development (4)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (11)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (11)


 

Breast Neoplasms (Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 1)

Corneal Endothelial Cell Loss (Phase 2)

Friedreich Ataxia (Phase 2)

General Surgery (Phase 2)

Healthy Volunteers (Phase 1)

Inflammation (Phase 2)

Liver Diseases (Phase 1)

Melanoma (Phase 1/Phase 2)

Mitochondrial Myopathies (Phase 2)

Pain (Phase 2)

Overview

  • Highest Phase: Phase 2
  • # of Trials: 13
  • # of Trial Organizations: 4

Trials by Phase

Trial Phase Start Date Organizations Indications

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