Active Ingredient History

  • Now
Octreotide (SMS 201-995, Sandostatin) is an octapeptide that exerts pharmacologic actions similar to the natural hormone, somatostatin. It was developed by Bauer and co-authors at Sandoz. It is an even more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Like somatostatin, it also suppresses LH response to GnRH, decreases splanchnic blood flow, and inhibits release of serotonin, gastrin, vasoactive intestinal peptide, secretin, motilin, and pancreatic polypeptide. By virtue of these pharmacological actions, Sandostatin has been used to treat the symptoms associated with metastatic carcinoid tumors (flushing and diarrhea), and Vasoactive Intestinal Peptide (VIP) secreting adenomas (watery diarrhea). Sandostatin substantially reduces growth hormone and/or IGF-I (somatomedin C) levels in patients with acromegaly. A radioactively labelled analogue has been used to visualize somatostatin receptors in a GRF-secreting human tumour.   NCATS

  • SMILES: C[C@@H](O)[C@@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](N)CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@H](CC4=CNC5=C4C=CC=C5)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1
  • Mol. Mass: 1019.239
  • ALogP: Missing data
  • ChEMBL Molecules:
More Chemistry

Drug Pricing (per unit)

United States

$1.2760 - $155.9333


$5.3325 - $53.3623
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

longastatin | ocreotide | octeotride | octreotida | octreotide | octreotide acetate | octreotide (acetate) | octreotide hydrochloride | octreotide pamoate | octreotidum | octrotide | sandostatin | sandostatine | sandostatin lar | sms-201-995 | sms 201-995 ac | sms-201-995 ac | sms 201-995 pa | sms pa | y90 resin microspheres


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