human factor ix complex (prothrombin complex concentrate) (Bebulin) Report issue

Biological Orphan Drug FDA Approved FDA
AACT ChEMBL DrugBank PubChem

Active Ingredient History

NOW
  • Now
Thrombin is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. Prothrombin is proteolytically cleaved to form thrombin in the clotting process. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions.   Wikipedia

Chemistry

More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

4-factor prothrombin complex concentrate | beriplex | coagulation factor ii | coagulation factor ii human | coagulation factor ii (human) | factor ii | factor ii (prothrombin) | factor ix complex | factor ix complex (human) | human coagulation factor ii | kcentra | pcc | prothrombin | prothrombin complex | prothrombin complex concentrate | prothrombin complex concentrate (human)

Organizations (42)

Research & Development (41)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (30)

Approved Indications (1)


 

Hemophilia B (approved 1970)

Experimental Indications - Clinical Trial Phases 1-4 (29)


 

Anticoagulants (Phase 4)

Bleeding Time (Phase 2)

Blood Coagulation (Phase 4)

Blood Coagulation Disorders (Phase 3)

Blood Loss, Surgical (Phase 4)

Blood Transfusion (Phase 2)

Bronchiectasis (Phase 4)

Cardiac Surgical Procedures (Phase 4)

Cardiovascular Surgical Procedures (Phase 4)

Deficiency Diseases (Phase 4)

Fibrin (Phase 2)

General Surgery (Phase 2)

Healthy Volunteers (Phase 1)

Heart Defects, Congenital (Phase 2)

Heart Diseases (Phase 3)

Heart Failure (Phase 3)

Hematologic Diseases (Phase 3)

Hemophilia A (Phase 3)

Hemorrhage (Phase 4)

Hemorrhagic Disorders (Phase 3)

Intracranial Hemorrhages (Phase 4)

Pharmacology (Phase 2)

Plasma (Phase 4)

Shock, Hemorrhagic (Phase 3)

Thrombosis (Phase 4)

Transfusion Reaction (Phase 2)

Transfusion-Related Acute Lung Injury (Phase 2)

Traumatology (Phase 3)

Vitamin K (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 37
  • # of Trial Organizations: 41

Trials by Phase

Trial Phase Start Date Organizations Indications

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