Active Ingredient History

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O6-Benzylguanine (O6-BG) is a synthetic derivative of guanine. It is an antineoplastic agent. It exerts its effect by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase which leads to interruption of DNA repair. O6-BG was used clinically in combination with the alkylating agent temozolomide for glioblastoma, however the combination was found to be overly toxic without adding significant benefit.   Wikipedia

More Chemistry
6-o-benzylguanine | benzylguanine | o(6)-benzylguanine | o6-benzylguanine | o(6)-bgua


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