nevirapine (viramune) Report issue

Small molecule Approved FDA Accelerated Approval FDA Priority Review FDA

Active Ingredient History

  • Now
Nevirapine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. Nevirapine is, in general, only prescribed after the immune system has declined and infections have become evident. It is always taken with at least one other HIV medication such as Retrovir or Videx. The virus can develop resistance to nevirapine if the drug is taken alone, although even if used properly, nevirapine is effective for only a limited time. Nevirapine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of nevirapine does not compete with template or nucleoside triphosphates. Nevirapine is used for use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.   NCATS

  • Mol. Mass: 266.2979
  • ALogP: 2.65
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.1387 - $19.1783


$1.3223 - $104.6655
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( lamivudine (epivir), nevirapine (viramune), zidovudine (retrovir) - other names: lamivudine/nevirapine/zidovudine tablets, lamivudine/zidovudine 150 mg/300 mg tablets co-packaged with nevirapine 200 mg tablets, lamivudine, zidovudine tabs 150mg/300mg co-packaged with nevirapine tabs 200mg )
11-cyclopropyl-5,11-dihydro-4-methyl-6h-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one | birg-0587 | gpo-vir | nev | nevarapine | nevirapine | nevirapine hemihydrate | nvp | stavudine - lamivudine - nevirapine | stavudine, lamivudine, nevirapine drug combination | triomune | viramune | viramune xr


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