Active Ingredient History

  • Now
Niacin (also known as vitamin B3 and nicotinic acid) is bio converted to nicotinamide which is further converted to nicotinamide adenine dinucleotide (NAD+) and the hydride equivalent (NADH) which are coenzymes necessary for tissue metabolism, lipid metabolism, and glycogenolysis. Niacin (but not nicotinamide) in gram doses reduces LDL-C, Apo B, Lp(a), TG, and TC, and increases HDL-C. The increase in HDL-C is associated with an increase in apolipoprotein A-I (Apo A-I) and a shift in the distribution of HDL subfractions. These shifts include an increase in the HDL2:HDL3 ratio, and an elevation in lipoprotein A-I (Lp A-I, an HDL-C particle containing only Apo A-I). The mechanism by which niacin alters lipid profiles is not completely understood and may involve several actions, including partial inhibition of release of free fatty acids from adipose tissue, and increased lipoprotein lipase activity (which may increase the rate of chylomicron triglyceride removal from plasma). Niacin decreases the rate of hepatic synthesis of VLDL-C and LDL-C, and does not appear to affect fecal excretion of fats, sterols, or bile acids. As an adjunct to diet, the efficacy of niacin and lovastatin in improving lipid profiles (either individually, or in combination with each other, or niacin in combination with other statins) for the treatment of dyslipidemia has been well documented. The effect of combined therapy with niacin and lovastatin on cardiovascular morbidity and mortality has not been determined. In addition, preliminary reports suggest that niacin causes favorable LDL particle size transformations, although the clinical relevance of this effect is not yet clear. April 15, 2016: Based on several large cardiovascular outcome trials including AIM-HIGH, ACCORD, and HPS2-THRIVE, the FDA decided that "scientific evidence no longer supports the conclusion that a drug-induced reduction in triglyceride levels and/or increase in HDL-cholesterol levels in statin-treated patients results in a reduction in the risk of cardiovascular events" Consistent with this conclusion, the FDA has determined that the benefits of niacin ER tablets for coadministration with statins no longer outweigh the risks, and the approval for this indication should be withdrawn.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Missing data
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.2947 - $4.9718
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

3-carboxypyridine | 3-pyridinecarboxylic acid | 3-pyridinecarboxylic acid methyl ester | 3-pyridylcarboxylic acid | acide nicotinique | acido nicotinico | acidum nicotinicum | anti-pellagra vitamin | beta-pyridinecarboxylic acid | chromium nicotinate | complamin | complamin ret | hexanicit | hexanicotinoyl inositol | hexanicotol | inositol hexaniacinate | inositol hexanicotinate | inositol niacinate | inositol nicotinate | laropiprant mixture with niacin | laropiprant / nicotinic acid | laropiprant /nicotinic acid | methyl 3-pyridinecarboxylate | methylnicotinate | methyl nicotinate | m-pyridinecarboxylic acid | myristyl nicotinate | niacin | niacin magnesium | niacin potassium | niacin td | niacor | niaspan | niaspan er | niaspan titration starter pack | nicangin | nicolar | nicotinate | nicotinic acid | nidadd | nikotinsaeure | pellagra preventive factor | p.p. factor | pp factor | pyridine-beta-carboxylic acid | pyridine-β-carboxylic acid | simcor | tocopheryl nicotinate | vitamin b3 | vitamin b3 (niacin) | vitathone | wampocap | xanthinol niacinate | xanthinol nicotinate | xantinol nicotinate | β-pyridinecarboxylic acid


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