Active Ingredient History

  • Now
Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury, which could lead to the need for a liver transplant, or even death. The incidence of severe liver damage is approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States. Within the serotonergic system, nefazodone acts as an antagonist at type 2 serotonin (5-HT2) post-synaptic receptors and, like fluoxetine-type antidepressants, inhibits pre-synaptic serotonin (5-HT) reuptake. These mechanisms increase the amount of serotonin available to interact with 5-HT receptors. Within the noradrenergic system, nefazodone inhibits norepinephrine uptake minimally. Nefazodone also antagonizes alpha(1)-adrenergic receptors, producing sedation, muscle relaxation, and a variety of cardiovascular effects. Nefazodone's affinity for benzodiazepine, cholinergic, dopaminergic, histaminic, and beta or alpha(2)-adrenergic receptors is not significant.   NCATS

More Chemistry

Drug Pricing (per unit)

United States

$1.1248 - $1.3692
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

1-(3-(4-(m-chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one | apo-nefazodone | apotex brand of nefazodone hydrochloride | bmy-13754 | bristol-myers brand of nefazodone hydrochloride | bristol-myers squibb brand of nefazodone hydrochloride | dutonin | europharma brand of nefazodone hydrochloride | hormosan brand of nefazodone hydrochloride | lin-nefazodone | linson pharma brand of nefazodone hydrochloride | menarini brand of nefazodone hydrochloride | menfazona | mj-13754-1 | nefadar | nefazodona | nefazodone | nefazodone hcl | nefazodone hydrochloride | nefazodonum | rulivan | serzone


Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue