trodusquemine Report issue

Small molecule Experimental
AACT ChEMBL MeSH PubChem

Active Ingredient History

NOW
  • Now
Trodusquemine is an aminosterol similar to squalamine that is an allosteric inhibitor of protein-tyrosine phosphatase 1B (PTP1B). It was isolated from the dogfish shark by scientists at Magainin Pharmaceuticals in 2000 and underwent some drug development as a potential treatment for diabetes or obesity, but the company ran out of money and closed in 2009.   Wikipedia

Chemistry

  • SMILES: CC(C)[C@@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@H]4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)NCCCNCCCCNCCCN)OS(=O)(=O)O
  • InChIKey: WUJVPODXELZABP-FWJXURDUSA-N
  • Mol. Mass: 685.07
  • ALogP: 5.53
  • ChEMBL Molecule:
    trodusquemine  
More Chemistry

Pharmacology

Alternative names

3beta-n-1(spermine)-7alpha, 24r-dihydroxy-5alpha-cholestane 24-sulfate | 3-n-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate | msi1436 | msi 1436 | msi-1436 | msi-1436c | trodusquemine

Organizations (7)

Research & Development (7)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (3)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (3)


 

Breast Neoplasms (Phase 1)

Diabetes Mellitus (Phase 1)

Obesity (Phase 1)

Overview

  • Highest Phase: Phase 1
  • # of Trials: 4
  • # of Trial Organizations: 7

Trials by Phase

Trial Phase Start Date Organizations Indications

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