Active Ingredient History

  • Now
Methimazole (also known as Tapazole or Thiamazole or MMI) is an antithyroid drug. Methimazole binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. So methimazole effectively inhibits the production of new thyroid hormones. Methimazole is used for the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.   NCATS

  • Mol. Mass: 114.169
  • ALogP: 1.08
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0459 - $0.2150
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

1-methyl-1,3-dihydro-2h-imidazole-2-thione | 1-methylimidazole-2(3h)-thione | danantizol | favistan | mercazolyl | methimazole | methylimidazolethiol | methymazol | strumazol | tapazole | thacapzol | thiamazol | thiamazole | thiamazolum | thycapzol | thymidazol | thymidazole | thyrozol | tiamazol | usaf el-30


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