Active Ingredient History

  • Now
Mangafodipir (sold under the brand name Teslascan as mangafodipir trisodium) is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver. Mangafodipir is a manganese (Mn2+) chelate with the ligand fodipir (dipyridoxyl diphosphate or DPDP). Mangafodipir trisodium is metabolised (dephosphorylated) and partially transmetallated (manganese exchanged for zinc) after intravenous administration. Manganese that is released from mangafodipir is taken up by hepatocytes thereby increasing the SI of normal liver tissue. This may result in an improvement of the detection of liver metastases, which usually have no hepatocytes. The metabolites of fodipir are renally excreted, whilst the biliary route mainly excretes manganese. Mangafodipir was withdrawn from the US market in 2003 and the European market in 2012.   NCATS

  • SMILES: [H+].[H+].[H+].[H+].[Mn++].CC1=NC=C(COP([O-])([O-])=O)C(CN(CCN(CC([O-])=O)CC2=C(COP([O-])([O-])=O)C=NC(C)=C2O)CC([O-])=O)=C1O
  • Mol. Mass: 691.3776
  • ALogP: Missing data
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Missing data
  • Pro Drug: No
ca4mn(dpdp)5 | calmangafodipir | dpdp | mangafodipir | mangafodipir trisodium | mangafodipir trisodium, anhydrous | manganese dipyridoxyl diphosphate | manganese-dpdp | mn-dpdp | n,n'-bis(pyridoxal-5-phosphate)ethylenediamine-n,n'-diacetic acid | nycomed brand of mangafodipir trisodium | teslascan | win-59010


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