Active Ingredient History
Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C (GC-C). Once linaclotide and its active metabolite binds to GC-C, it has local effect on the luminal surface of the intestinal epithelium. Activation of GC-C by linaclotide results in the intra- and extracellular increase of cyclic guanosine monophosphate concentrations (cGMP). This elevation of cGMP levels stimulates the secretion of chloride and bicarbonate into the intestinal lumen via activation of cystic fibrosis transmembrane conductance regulator (CFTR) ion channel. The metabolite of linaclotide MM-419447 (CCEYCCNPACTGC) contributes to the pharmacologic effects of linaclotide. Ultimately, linaclotide helps patients with IBS (especially with constipation) as GI transit is accelerated and the release of intestinal fluid is increased. In animal models, a decrease in visceral pain after administration of linaclotide may be observed. A decrease in the activity of pain-sensing nerves occurs as a result of an increase in extracellular cGMP. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Abdominal Pain (Early Phase 1)
Arthritis, Rheumatoid (Phase 2)
Barrett Esophagus (Early Phase 1)
Breast Feeding (Phase 1)
Colitis, Ulcerative (Phase 4)
Colorectal Neoplasms (Phase 2)
Constipation ()
Crohn Disease (Phase 4)
Diabetes Mellitus (Phase 4)
Dyspepsia (Phase 4)
Gastroesophageal Reflux (Early Phase 1)
Healthy Volunteers (Phase 1)
Intestinal Neoplasms (Phase 4)
Opioid-Induced Constipation (Phase 2)
Pharmacokinetics (Phase 1)
Trial | Phase | Start Date | Organizations | Indications |
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