Active Ingredient History

  • Now
Levocabastine (trade name Livo) is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis. Levocabastine binds the G protein-coupled neurotensin receptor 2 (NTR2), but not NTR1, where it behaves as a weak partial inverse agonist. In an environmental study, LIVOSTIN 0.05% (levocabastine hydrochloride ophthalmic suspension) instilled four times daily was shown to be significantly more effective than its vehicle in reducing ocular itching associated with seasonal allergic conjunctivitis. After instillation in the eye, levocabastine is systemically absorbed. However, the amount of systemically absorbed levocabastine after therapeutic ocular doses is low (mean plasma concentrations in the range of 1-2 ng/mL). Brand name Livostin is no longer available in the U.S., but generic versions may still be available. Common side effects include burning, stinging, itching, or watering of the eyes, eye irritation or discomfort, blurred vision, dry or puffy eyes, headache, nosebleed, nausea, or fatigue.   NCATS

  • SMILES: C[C@@H]1CN(CC[C@]1(C(=O)O)c2ccccc2)[C@@H]3CC[C@@](CC3)(C#N)c4ccc(F)cc4
  • Mol. Mass: 420.53
  • ALogP: 4.89
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Topical
  • Pro Drug: No
1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-4-piperidinecarboxylic acid | bilina | chauvin brand of levocabastine hydrochloride | ciba vision brand of levocabastine hydrochloride | esteve brand of levocabastine hydrochloride | iolab brand of levocabastine hydrochloride | janssen brand of levocabastine hydrochloride | levocabastin | levocabastina | levocabastine | levocabastine hcl | levocabastine hydrochloride | levocabastinum | levophta | lévophta | livocab | livostin | livostin direct | r-50547 | taxandria brand of levocabastine hydrochloride | winzer brand of levocabastine hydrochloride


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