Active Ingredient History

  • Now
Irbesartan is an angiotensin receptor blocker (ARB) used mainly for the treatment of hypertension. It was developed by Sanofi Research (now part of Sanofi-Aventis). It is marketed under the trade names Aprovel, Karvea, and Avapro. AVAPRO is an angiotensin II receptor blocker (ARB) indicated for: • Treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. • Treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes, an elevated serum creatinine, and proteinuria. Irbesartan is a specific competitive antagonist of AT1 receptors with a much greater affinity (more than 8500-fold) for the AT1 receptor than for the AT2 receptor and no agonist activity.   NCATS

  • Mol. Mass: 428.5294
  • ALogP: 4.78
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)


$0.0416 - $0.1638

United States

$0.1649 - $8.0124
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( irbesartan (avapro), hydrochlorothiazide (esidrix) - other name: irbesartan hydrochlorothiazide )
1,3-diazaspiro(4.4)non-1-en-4-one, 2-butyl-3-((2'-(1h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)- | 2-butyl-3-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one | 2-n-butyl-3-((2'-(1h-tetrazol-5-yl)biphenyl-4-yl)methyl)-1,3-diazaspiro(4,4)non-1-en-4-one | aprovel | avapro | bms 186295 | bms-186295 | ibesartan | ifirmasta | irbesartan | irbesartan hcl | irbesartan hydrochloride | irbesartan / hydrochlorothiazide | irbesartan: hydrochlorothiazide | karvea | sabervel | sr 47436 | sr-47436


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