Active Ingredient History

  • Now
Levodopa (L-DOPA) was first isolated from seedlings of Vicia faba by Marcus Guggenheim in 1913. Levodopa, a dopamine precursor, is an effective and well-tolerated dopamine replacement agent used to treat Parkinson's disease. Oral levodopa has been widely used for over 40 years, often in combination with a dopa-decarboxylase inhibitor carbidopa, which reduces many treatment complications, extending its half-life and increasing levodopa availability to the brain. Entacapone, a catechol-O-methyltransferase inhibitor, can also be used to improve the bioavailability of levodopa, especially when used in conjunction with a carbidopa.   NCATS

  • SMILES: N[C@@H](CC1=CC(O)=C(O)C=C1)C(O)=O
  • Mol. Mass: 197.1879
  • ALogP: 0.05
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( levodopa (larodopa), carbidopa (sinemet) - other names: carbidopa and levodopa, carbilev, duopa, parcopa, rytary, sinemet cr, wd-1603 carbidopa-levodopa extended-release tablets )
(−)-3-(3,4-dihydroxyphenyl)-l-alanine | 3,4-dihydroxy-l-phenylalanine | 3-hydroxy-l-tyrosine | bendopa | brocadopa | carbidopa-levodopa | dihydroxy-l-phenylalanine | dihydroxyphenylalanine | dopa | (−)-dopa | dopar | etilevodopa | l-3,4-dihydroxyphenylalanine | larodopa | l-beta-(3,4-dihydroxyphenyl)alanine | l-dopa | ledopa | levodopa | levodopa / carbidopa | levodopa / carbidopa / entacapone | levodopa ethyl ester | levodopum | tv-1203 | β-(3,4-dihydroxyphenyl)alanine | β-(3,4-dihydroxyphenyl)-l-alanine


Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue