Active Ingredient History

  • Now
Indapamide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Indapamide blocks the slow component of delayed rectifier potassium current (IKs) without altering the rapid component (IKr) or the inward rectifier current. Specifically it blocks or antagonizes the action the proteins KCNQ1 and KCNE1. Indapamide is also thought to stimulate the synthesis of the vasodilatory hypotensive prostaglandin PGE2. Indapamide is used for the treatment of hypertension, alone or in combination with other antihypertensive drugs, as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy (appropriate only in the management of edema of pathologic origin during pregnancy when clearly needed). Also used for the management of edema as a result of various causes.   NCATS

  • SMILES: CC1CC2=CC=CC=C2N1NC(=O)C3=CC(=C(Cl)C=C3)S(N)(=O)=O
  • Mol. Mass: 365.835
  • ALogP: 2.08
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)


$0.0458 - $0.1280

United States

$0.1397 - $0.3757
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

cardide sr | ethibide xl | flupamid | indaflex | indamide | indamol | indapamid | indapamida | indapamide | (+/-)-indapamide | indapamide hemihydrate | indapamidum | indaxa 2.5 | indipamide | indipam xl | lozol | mapemid xl | metindamide | natrilix | natrilix sr | nindaxa 2.5 | opumide 2.5 | rawel xl | tensaid xl | varbim xl | veroxil


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