Active Ingredient History

  • Now
Idoxuridine is an antiviral agent use in keratitis caused by herpes simplex virus. As a prescription drug it comes as a 0.1% ophthalmic solution/drops (Herplex and Dendrid). The first studies of the compound for treatment of human herpes simplex started in early 1960s. Being a structural analog of thymidine idoxuridine inhibits viral DNA replication by substituting thymidine. The effect of idoxuridine results in the inability of the virus to reproduce and/or infect tissues. Idoxuridine also blocks viral thymidine kinase as its substrate analog.   NCATS

  • SMILES: OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(I)C(=O)NC2=O
  • Mol. Mass: 354.0985
  • ALogP: -1.22
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Topical
  • Pro Drug: No
1-(2-deoxy-beta-d-ribofuranosyl)-5-iodouracil | 1-beta-d-2'-deoxyribofuranosyl-5-iodouracil | 1beta-d-2'-deoxyribofuranosyl-5-iodouracil | 2'-deoxy-5-iodouridine | 5-fluorodeoxyuridine | (+)-5-iodo-2'-deoxyuridine | 5-iodo-2'-deoxyuridine | 5-iododeoxyuridine | 5-iodouracil deoxyriboside | 5iudr | allergan | allergan 211 | allergan-211 | dendrid | herplex | idox | idoxene | idoxuridin | idoxuridina | idoxuridine | idoxuridinum | idu | iododeoxyridine | iododeoxyuridine | iodoxuridine | joddeoxiuridin | kerecid | ophthalmadine | sk&f-14287 | stoxil


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