Active Ingredient History

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Ibipinabant (SLV319, BMS-646,256) is a drug used in scientific research which acts as a potent and highly selective CB1 antagonist. It has potent anorectic effects in animals, and was researched for the treatment of obesity, although CB1 antagonists as a class have now fallen out of favour as potential anorectics following the problems seen with rimonabant, and so ibipinabant is now only used for laboratory research, especially structure-activity relationship studies into novel CB1 antagonists. SLV330, which is a structural analogue of Ibipinabant, was reported active in animal models related to the regulation of memory, cognition, as well as in addictive behavior. An atom-efficient synthesis of ibipinabant has been reported.   Wikipedia

  • SMILES: CN\C(=N/S(=O)(=O)c1ccc(Cl)cc1)\N2C[C@@H](C(=N2)c3ccc(Cl)cc3)c4ccccc4
  • Mol. Mass: 487.41
  • ALogP: 4.76
  • ChEMBL Molecule:
More Chemistry
3-(4-chlorophenyl)-n-((4-chlorophenyl)sulfonyl)-4,5-dihydro-n'-methyl-4-phenyl-1h-pyrazole-1-carboximidamide | 3-(4-chlorophenyl)-n-methyl-n'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1h-pyrazole-1-carboxamidine | bms-646256 | ibipinabant | slv319 | slv 319 | slv-319


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