Active Ingredient History
Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Insulin lowers blood glucose levels by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis in adipocytes, inhibits proteolysis, and enhances protein synthesis. Human insulin begins to exert its effects within 30 minutes of subcutaneous administration, while peak levels occur 3-4 hours after administration. Due to its quick onset of action, human insulin is considered "bolus insulin" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the pancreas after meals. Bolus insulin is often combined with once daily, long-acting "basal insulin" to provide low concentrations of background insulin that can keep blood sugar stable between meals or overnight. Use of basal and bolus insulin together is intended to mimic the pancreas' production of endogenous insulin, with a goal of avoiding any periods of hypoglycemia. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Acromegaly (Phase 4)
Acute Coronary Syndrome (Phase 4)
Acute Kidney Injury (Phase 2)
Adrenal Gland Neoplasms (Phase 2)
Adrenal Insufficiency (Phase 2)
AIDS Dementia Complex (Phase 1/Phase 2)
Alzheimer Disease (Phase 2/Phase 3)
Androgens (Phase 2)
Angina, Unstable (Phase 3)
Angiogenesis Modulating Agents (Phase 3)
Anhedonia (Early Phase 1)
Anosmia (Phase 2)
Aortic Aneurysm (Phase 1)
Arrhythmias, Cardiac (Phase 4)
Asthma (Phase 3)
Atherosclerosis (Phase 4)
Atrophy (Phase 4)
Auditory Diseases, Central (Phase 4)
Autonomic Nervous System Diseases (Phase 1)
Bariatric Surgery (Phase 4)
Bipolar Disorder (Phase 3)
Blood Glucose (Phase 3)
Brain Injuries (Phase 4)
Brain Injuries, Traumatic (Phase 4)
Brain Ischemia (Phase 3)
Brain Neoplasms (Early Phase 1)
Burns (Phase 2/Phase 3)
Cachexia (Phase 4)
Cardiac Surgical Procedures (Phase 3)
Cardiopulmonary Bypass (Phase 2)
Cardiovascular Diseases (Phase 3)
Carpal Tunnel Syndrome (Early Phase 1)
Cognition Disorders (Phase 3)
Cognitive Dysfunction (Phase 2)
Colonic Neoplasms (Phase 4)
Colorectal Neoplasms (Phase 4)
Coronary Artery Bypass (Phase 4)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 3)
Coronary Restenosis (Phase 4)
Coronavirus Infections (Phase 4)
COVID-19 (Phase 3)
Critical Illness (Phase 2)
Cystic Fibrosis (Phase 4)
Delirium (Phase 1/Phase 2)
Dementia (Phase 2)
Depressive Disorder, Major (Phase 3)
Diabetes, Gestational (Phase 4)
Diabetes Mellitus, Type 1 (Phase 4)
Diabetic Ketoacidosis (Phase 4)
Diabetic Nephropathies (Phase 4)
Diabetic Retinopathy (Phase 3)
Drugs, Investigational (Phase 4)
Dry Eye Syndromes (Phase 1)
Endocrine System Diseases (Phase 4)
Erectile Dysfunction (Phase 4)
Fibrosis (Phase 4)
General Surgery (Phase 4)
Gestational Age (Phase 3)
Glaucoma (Phase 1)
Glucagon (Phase 1)
Glucose Intolerance (Phase 4)
Glucose Metabolism Disorders (Phase 4)
Glycemic Control (Phase 4)
Graft Rejection (Phase 4)
Growth Hormone (Phase 3)
Healthy Volunteers (Phase 4)
Heart (Phase 1)
Heart Diseases (Phase 4)
Heart Failure (Phase 4)
Heart Valve Diseases (Phase 1)
Hemorrhage (Phase 4)
Hypercholesterolemia (Phase 3)
Hyperglycemia (Phase 4)
Hyperinsulinism (Phase 1)
Hyperkalemia (Phase 2)
Hypertension (Phase 4)
Hypertriglyceridemia (Phase 4)
Hypoglycemia (Phase 4)
Hypogonadism (Phase 1/Phase 2)
Infant, Premature (Phase 3)
Inpatients (Phase 4)
Insulin (Phase 4)
Insulin Resistance (Phase 4)
Intestinal Neoplasms (Phase 4)
Intracranial Aneurysm (Early Phase 1)
Intracranial Hemorrhages (Phase 4)
Intraoperative Complications (Early Phase 1)
Ischemic Stroke (Phase 4)
Kidney Failure, Chronic (Phase 4)
Labor Pain (Phase 3)
Leukemia (Phase 3)
Liver Cirrhosis (Phase 4)
Liver Transplantation (Phase 4)
Lymphoma (Early Phase 1)
Memory Disorders (Phase 1)
Metabolic Diseases (Phase 4)
Metformin (Phase 2)
Multiple Sclerosis, Chronic Progressive (Phase 1/Phase 2)
Multiple Sclerosis, Relapsing-Remitting (Phase 1/Phase 2)
Multiple System Atrophy (Phase 2)
Myocardial Infarction (Phase 4)
Myocardial Ischemia (Phase 1)
Non-alcoholic Fatty Liver Disease (Phase 2)
Obesity (Phase 4)
Olfaction Disorders (Phase 2)
Out-of-Hospital Cardiac Arrest (Phase 1)
Oxidative Stress (Phase 4)
Pancreatic Neoplasms (Phase 4)
Pancreatitis (Phase 4)
Parkinson Disease (Phase 2)
Pediatric Obesity (Phase 4)
Peripheral Vascular Diseases (Phase 4)
Peritoneal Dialysis (Phase 4)
Pharmacokinetics (Phase 4)
Pituitary ACTH Hypersecretion (Phase 4)
Pregnancy (Phase 3)
Pregnancy Complications (Phase 3)
Pregnancy, High-Risk (Phase 4)
Pregnancy in Diabetics (Phase 4)
Premature Birth (Phase 2)
Pressure Ulcer (Phase 1/Phase 2)
Psychological Distress (Phase 3)
Psychotic Disorders (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 3)
Quality of Life (Phase 2/Phase 3)
Regional Blood Flow (Phase 2)
Renal Insufficiency (Phase 4)
Renal Insufficiency, Chronic (Phase 4)
Respiratory Distress Syndrome (Phase 2)
Respiratory Insufficiency (Phase 3)
Respiratory Tract Infections (Phase 2)
Retina (Phase 2)
Sarcopenia (Phase 1)
Schizophrenia (Phase 4)
Sepsis (Phase 3)
Shock, Septic (Phase 3)
Short Bowel Syndrome (Phase 2/Phase 3)
Smoking Cessation (Phase 2)
Stress Disorders, Post-Traumatic (Phase 2)
Stroke (Phase 4)
Subarachnoid Hemorrhage (Phase 4)
Therapeutics (Phase 2)
Thoracic Surgery (Phase 2)
Tobacco (Phase 2)
Traumatology (Phase 4)
Vascular Stiffness (Early Phase 1)
Vasodilation (Early Phase 1)
Ventricular Dysfunction (Phase 1)
Weight Gain (Phase 4)
Wound Healing (Phase 4)
Wounds and Injuries (Phase 1/Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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