Active Ingredient History

  • Now
Histrelin is a gonadotropin releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant that delivers continuous therapeutic doses. Following an initial stimulatory phase with increased circulating levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a transient increase in concentration of gonadal steroids (testosterone and dihydrotestosterone in males), continuous administration of histrelin acetate results in decreased levels of LH and FSH due to a reversible down-regulation of the GnRH receptors in the pituitary gland and desensitization of the pituitary gonadotropes. As the product Supprelin LA (FDA), histrelin is indicated for the treatment of children with central precocious puberty (CPP). As the product Vantas (FDA), histrelin is indicated for the palliative treatment of advanced prostate cancer.   NCATS

  • SMILES: CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2cn(Cc3ccccc3)cn2)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CO)NC(=O)[C@H](Cc5c[nH]c6ccccc56)NC(=O)[C@H](Cc7cnc[nH]7)NC(=O)[C@@H]8CCC(=O)N8
  • Mol. Mass: 1323.53
  • ALogP: Missing data
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$2848.1400 - $38961.1000
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

5-oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-1-benzyl-d-histidyl-l-leucyl-l-arginyl-n-ethyl-l-prolinamide | 5-oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-nτ-benzyl-d-histidyl-l-leucyl-l-arginyl-n-ethyl-l-prolinamide | 6-his(imbzl)-9-n-et-pronh2-10-des-glynh2-lhrh | gnrh, his(imbzl)(6)-n-et-pronh2(9)- | histrelin | histrelina | histrelin acetate | histreline | histrelinum | ibhpe-lhrh | [(im-bzl)-d-his6,pro9-net]-gonadotropin releasing hormone | ((im bzl)-d-his(6), pro(9)-net)lhrh | imbzl-his(6), pro(9)-net-gnrh | lhrh, his(imbzl)(6)-n-et-pronh2(9)- | lhrh, histidyl(imbzl)(6)-n-ethylprolinamide(9)-des-glycinamide(10)- | l-pyroglutamyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-d-nim-benzyl-histidyl-l-leucyl-l-arginyl-l-proline ethylamide | luteinizing hormone-releasing factor, 6-(1-(phenylmethyl)-d-histidine)-9-(n-ethyl-l-prolinamide)-10-deglycinamide- | luteinizing hormone-releasing factor (pig) | orf-17070 | rwj-17070 | supprelin | supprelin la | vantas


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