Active Ingredient History

  • Now
Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to ethinyl estradiol before it is biologically active. Ethinyl estradiol and norethindrone are used together as an oral contraceptive agent. Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH). Used for treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.   NCATS

  • SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(O)=CC=C34)[C@@H]1CC[C@@]2(O)C#C
  • Mol. Mass: 296.4034
  • ALogP: 3.61
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral, Topical
  • Pro Drug: No

Combination drugs

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( etynodiol acetate, ethinyl estradiol (Estinyl) - other names: kelnor, lo-malmorede, malmorede, zovia 1/35e, zovia 1/50e )
( ethinyl estradiol (Estinyl), desogestrel (Mercilon) - other names: bekyree, cyclessa, desogestrel; ethinyl, emoquette, enskyce, isibloom, kalliga, kariva, kimidess, mircette, nuvaring, ortho-cept, pimtrea, velivet, viorele, volnea )
( ethinyl estradiol (Estinyl), norethindrone - other names: alyacen, aranelle, aurovela, aurovela 24 fe, aurovela fe, balziva, blisovi 24 fe, blisovi fe, brevicon, briellyn, cyclafem, cyonanz, dasetta, estrostep, estrostep fe, femcon fe, femhrt, fyavolv, gencept, gildagia, gildess, gildess 24 fe, gildess fe, hailey, hailey fe, junel, junel fe, kaitlib fe, larin, larin 24 fe, larin fe, leribane, loestrin, loestrin 24 fe, lo larin fe, lo loestrin fe, lo minastrin fe, mibelas 24 fe, microgestin, microgestin fe, minastrin 24 fe, modicon, n.e.e, nexesta fe, norcept-e, norethin 1/35e, norethindrone acetate and ethinyl estradiol and ethinyl estradiol and ferrous fumarate, norethindrone acetate and ethinyl estradiol and ferrous fumarate, norethindrone and ethinyl estradiol (10/11), norethindrone and ethinyl estradiol (7/14), norethindrone and ethinyl estradiol and ferrous fumarate, nortrel, nylia, ovcon, philith, pirmella, taytulla, tri-legest, tri-legest fe, tri-norinyl, vyfemla, wera )
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( ferric fumarate, ethinyl estradiol (Estinyl), norethindrone - other names: lo-blisovi fe, norquest fe )
( ethinyl estradiol (Estinyl), norgestimate - other names: estarylla, mili, mono-linyah, ortho tri-cyclen, ortho tri-cyclen lo, previfem, sprintec, tri-estarylla, tri-linyah, tri-lo-estarylla, tri-lo-linyah, tri-lo-mili, tri lo sprintec, tri-mili, tri-previfem, tri-sprintec )
( ethinyl estradiol (Estinyl), norelgestromin (Evra) - other name: xulane )
( norgestrel (Ovral), ethinyl estradiol (Estinyl) - other names: afirmelle, alesse, altavera, ashlyna, aviane, ayuna, balcoltra, cerinta, cryselle, daysee, elifemme, elinest, enpresse, falmina, fayosim, iclevia, introvale, jaimiess, kurvelo, lessina, levlite, levonest, levonorgestrel and ethinyl estradiol and ethinyl estradiol, levora, lo/ovral, loseasonique, lo simpesse, low-ogestrel, lybrel, marlissa, myzilra, nordette, ogestrel, orsythia, portia, preven emergency contraceptive, quartette, quasense, seasonale, seasonique, setlakin, simpesse, sylevia, triphasil, trivora, vienva )
( ethinyl estradiol (Estinyl), drospirenone (Yasmin) - other names: kemeya, kyra, loryna, lo-zumandimine, melamisa, nikki, syeda, yaela, yaz, zumandimine )
(17 alpha)-17-hydroxy-19-norpregn-4-en-20-yn-3-one, mixture with (17 alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol | 17alpha-ethinyl estradiol | 17 alpha-hydroxy-19-norpregn-5(10)-en-20-yn-3- one mixt. with (17 alpha)-3-methoxy-19-norpregna- 1,3,5(10)-trien-20-yn-17-ol | 17-ethinyl-3,17-estradiol | 17-ethinyl-3,17-oestradiol | 17-ethinylestradiol | 17α-ethynylestradiol | 19-norpregn-4-en-20-yne-3 beta,17 alpha-diol diacetate mixt. with 3-methoxy-19-norpregna-1,3,5(10) trien-20-yn-17 alpha-ol | angravid | anovlar | binovum | bisecurin | bisecurin i | brevicon | brevion | con-fer | drospirenone and ethinyl estradiol combination | drospirenone, ethinyl estradiol drug combination | dt 5061 | dt-5061 | enovid | enovid-e | enovid, noretynodrel | estinyl | estrostep | ethinyl esteradiol | ethinylestradiol | ethinyl estradiol | ethinyl-estradiol | ethinylestradiol betadex | ethinylestradiolum | ethinyloestradiol | ethynylestradiol | ethynyl estradiol | ethynylestradiol mixture with norethindrone | etinestryl | etinilestradiol | feminone | follicoral | ginestrene | infecundin | lodose | loestrin | loveston | lynoral | mestranol | modicon | neocon | netasyn | norelgestromin / ethinyl estradiol | norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination | norimen | norinyl | norinyl 1-35 | norminest | ortho novum 7-7-7 | ovaras | ovulen | ovulen-21 | ovulen-28 | ovyrmen | primidos | sesquelan | sh 7.1122 | sh b 259 ab | synphase | triella | tri-norinyl | trinovum | yasmin | yasminelle | yaz | yaz combination | zoran


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