Active Ingredient History

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Fosmidomycin is an antibiotic that was originally isolated from culture broths of bacteria of the genus Streptomyces. It specifically inhibits DXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. It is a structural analogue of 2-C-methyl-D-erythrose 4-phosphate. It inhibits the E. coli enzyme with a KI value of 38 nM (4), MTB at 80 nM, and the Francisella enzyme at 99 nM. Several mutations in the E. coli DXP reductoisomerase were found to confer resistance to fosmidomycin.   Wikipedia

  • SMILES: ON(CCCP(=O)(O)O)C=O
  • InChIKey: GJXWDTUCERCKIX-UHFFFAOYSA-N
  • Mol. Mass: 183.1
  • ALogP: -0.6
  • ChEMBL Molecule:
More Chemistry
(3-(formylhydroxyamino)propyl)phosphonic acid, monosodium salt | 3-(n-formyl-n-hydroxy)aminopropylphosphonic acid | fosfidomycin | fosmidomycin | fosmidomycin monoammonium salt | fosmidomycin monopotassium salt | fosmidomycin monosodium salt | fosmidomycin sodium | fosmidomycin sodium salt | fr-31564 | phosphonic acid, (3-(formylhydroxyamino)propyl)-, monosodium salt

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