Active Ingredient History

  • Now
Galantamine (RAZADYNE®, galantamine hydrobromide) is a benzazepine derived from norbelladine. It is found in Galanthus and other Amaryllidaceae. It is a reversible, competitive acetylcholinesterase inhibitor that is used for the treatment of mild to moderate dementia of the Alzheimer’s type. Although the etiology of cognitive impairment in Alzheimer’s disease is not fully understood, it has been reported that acetylcholine-producing neurons degenerate in the brains of patients with Alzheimer’s disease. The degree of this cholinergic loss has been correlated with degree of cognitive impairment and density of amyloid plaques (a neuropathological hallmark of Alzheimer’s disease). While the precise mechanism of galantamine’s (RAZADYNE®, galantamine hydrobromide) action is unknown, it is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this mechanism is correct, galantamine’s (RAZADYNE®, galantamine hydrobromide) effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that galantamine (RAZADYNE®, galantamine hydrobromide) alters the course of the underlying dementing process.   NCATS

  • SMILES: COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24
  • Mol. Mass: 287.36
  • ALogP: 1.85
  • ChEMBL Molecules:
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  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0147 - $10.6190


$0.6058 - $0.8830
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

acumor xl | consion xl | elmino xl | galantamin | galantamina | galantamine | (-)-galantamine | galantamine hydrobromide | galanthamine | (-)-galanthamine | galanthamine hydrobromide | galsya xl | galzemic xl | gatalin xl | gazylan xl | lotprosin xl | luventa xl | lycoremin | lycoremine | razadyne | razadyne er | reminyl | reminyl xl | zeebral xl


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