Active Ingredient History
Нeparin (or Unfractionated heparin ) is an anticoagulant indicated for both the prevention and treatment of thrombotic events such as deep vein thrombosis (DVT) and pulmonary embolism (PE) as well as atrial fibrillation (AF). Heparin can also be used to prevent excess coagulation during procedures such as cardiac surgery, extracorporeal circulation or dialysis, including continuous renal replacement therapy. Heparin administration can be by intravenous (or subcutaneous route. Intravenous heparin is continuously administered for therapeutic anticoagulation, while intermittent subcutaneous administration is used to prevent thromboembolism. Once administered, heparin binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. The heparin-ATIII complex can also inactivate factors IX, XI, XII, and plasmin, but the antithrombotic effect of heparin is well correlated to the inhibition of factor Xa. Typical adverse effects from heparin use include bleeding, thrombocytopenia, injection site reactions, and other adverse effects only seen with chronic heparin administration. Bleeding is a major complication associated with heparin use. Patients should undergo monitoring for new bleeding that may present in the urine or stool. Bleeding may also present as bruising, petechial rash and nosebleeds. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abortion, Habitual (Phase 4)
Abortion, Spontaneous (Phase 4)
Acute Chest Syndrome (Phase 2)
Acute Coronary Syndrome (Phase 4)
Acute Kidney Injury (Phase 4)
Acute Lung Injury (Phase 4)
Aged (Phase 4)
Aging (Phase 4)
Anemia, Aplastic (Phase 3)
Anemia, Sickle Cell (Phase 2)
Anesthesia (Phase 4)
Angina Pectoris (Phase 4)
Angina, Stable (Phase 4)
Angina, Unstable (Phase 4)
Angioplasty, Balloon, Coronary (Phase 3)
Anticoagulants (Phase 4)
Antithrombins (Phase 1/Phase 2)
Aortic Stenosis, Subvalvular (Phase 3)
Aortic Valve Disease (Phase 3)
Arterial Occlusive Diseases (Phase 2)
Arteriovenous Fistula (Phase 4)
Bacteremia (Phase 4)
Bacterial Infections (Phase 3)
Bile Duct Neoplasms (Phase 2)
Blood Circulation (Phase 4)
Blood Coagulation (Phase 3)
Burns (Phase 3)
Cardiac Catheterization (Phase 2)
Cardiopulmonary Bypass (Phase 4)
Cardiovascular Diseases (Phase 3)
Catheter-Related Infections (Phase 4)
Catheters (Phase 4)
Chemotherapy, Adjuvant (Phase 1)
Cholangiocarcinoma (Phase 2)
Colorectal Neoplasms (Phase 3)
Contusions (Phase 4)
Coronary Angiography (Phase 4)
Coronary Artery Bypass (Phase 3)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 4)
Coronary Vasospasm (Phase 4)
COVID-19 (Phase 4)
Critical Illness (Phase 3)
Cystitis, Interstitial (Phase 2)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 1 (Phase 2)
Dialysis (Phase 2)
Disseminated Intravascular Coagulation (Phase 3)
Drugs, Investigational (Phase 4)
Embolic Stroke (Phase 2)
Embolism (Phase 3)
Esophageal and Gastric Varices (Phase 4)
Extracorporeal Circulation (Phase 4)
Extracorporeal Membrane Oxygenation (Phase 4)
Fertilization in Vitro (Phase 3)
Fibrinolysis (Phase 3)
Fibrosis (Phase 4)
General Surgery (Phase 4)
Healthy Volunteers (Phase 1)
Heart Diseases (Phase 3)
Heart Failure (Phase 4)
Hemodialysis, Home (Phase 4)
Hemodilution (Phase 3)
Hemorrhage (Phase 4)
Heparin (Phase 4)
Hip Fractures (Phase 3)
Hypertension, Portal (Phase 1/Phase 2)
Hypoxia (Phase 2/Phase 3)
Infections (Phase 3)
Infertility (Phase 2/Phase 3)
Inhalation Exposure (Phase 3)
Intracranial Aneurysm (Phase 2)
Ischemic Stroke (Phase 4)
Kidney Diseases (Phase 4)
Kidney Failure, Chronic (Phase 4)
Liver Cirrhosis (Phase 1/Phase 2)
Liver Neoplasms (Phase 2/Phase 3)
Lower Urinary Tract Symptoms (Phase 2)
Malaria, Falciparum (Phase 2/Phase 3)
Mesenteric Ischemia (Phase 4)
Metabolic Diseases (Phase 3)
Myocardial Infarction (Phase 4)
Myocardial Ischemia (Phase 4)
Neoplasm Metastasis (Phase 3)
Neoplasms (Phase 3)
Neurobehavioral Manifestations (Phase 2)
Obesity (Phase 4)
Osteoarthritis (Phase 4)
Pediatrics (Phase 4)
Percutaneous Coronary Intervention (Phase 4)
Pharmacokinetics (Phase 2/Phase 3)
Phlebitis (Phase 4)
Pneumonia (Phase 4)
Pneumonia, Viral (Phase 4)
Postoperative Complications (Phase 2)
Postoperative Hemorrhage (Phase 3)
Postthrombotic Syndrome (Phase 3)
Pregnancy (Phase 4)
Pregnancy Complications (Phase 4)
Prostatic Neoplasms (Phase 4)
Renal Dialysis (Phase 4)
Renal Insufficiency (Phase 3)
Renal Insufficiency, Chronic (Phase 4)
Respiration, Artificial (Phase 4)
Respiratory Distress Syndrome (Phase 4)
Respiratory Insufficiency (Phase 4)
Retinal Artery Occlusion (Phase 3)
Sepsis (Phase 4)
Shock, Cardiogenic (Phase 2)
Shock, Septic (Phase 2)
Sinus Thrombosis, Intracranial (Phase 2/Phase 3)
ST Elevation Myocardial Infarction (Phase 4)
Stomatitis (Phase 1)
Stroke (Phase 3)
Subarachnoid Hemorrhage (Phase 3)
Thoracic Surgery (Phase 4)
Thrombocytopenia (Phase 4)
Thromboembolism (Phase 4)
Thrombophilia (Phase 4)
Thrombophlebitis (Phase 1)
Thrombosis (Phase 4)
Transcatheter Aortic Valve Replacement (Phase 3)
Upper Extremity Deep Vein Thrombosis (Phase 4)
Urinary Bladder Diseases (Phase 2)
Urinary Tract Infections (Phase 1/Phase 2)
Vascular Access Devices (Phase 4)
Vascular Diseases (Phase 4)
Vasospasm, Intracranial (Phase 2)
Venous Thromboembolism (Phase 4)
Ventilation (Phase 4)
Visual Acuity (Phase 3)
Vulvodynia (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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