Active Ingredient History
Nitroglycerin was first invented in 1847 and has been used as an active ingredient in the manufacture of explosives, mostly dynamite. Nitroglycerin came into medical use in 1878 as as a potent vasodilator (dilation of the vascular system) to treat heart conditions, such as angina pectoris and chronic heart failure. Upon administration, nitroglycerin is converted to nitric oxide (NO) by mitochondrial aldehyde dehydrogenase. NO is a potent activator of guanylyl cyclase (GC) by heme-dependent mechanisms. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Heart Failure (approved 1981)
Anemia, Sickle Cell (Phase 2)
Anesthesia (Phase 2)
Angina Pectoris (Phase 4)
Angina, Stable (Phase 4)
Arterial Occlusive Diseases (Phase 3)
Arthritis, Rheumatoid (Phase 3)
Atherosclerosis (Phase 3)
Autoimmune Diseases (Phase 3)
Biliary Tract Diseases (Phase 2)
Bone Diseases, Metabolic (Phase 3)
Carcinoma, Non-Small-Cell Lung (Phase 2)
Cardiac Catheterization (Phase 3)
Cardiovascular Diseases (Phase 4)
Catheter-Related Infections (Phase 1/Phase 2)
Cerebral Hemorrhage (Phase 2)
Chest Pain (Phase 2)
Cholangiopancreatography, Endoscopic Retrograde (Phase 2/Phase 3)
Colic (Phase 2)
Colonic Polyps (Phase 1)
Colorectal Neoplasms (Early Phase 1)
Coronary Disease (Phase 4)
Diabetes Mellitus (Phase 2)
Erectile Dysfunction (Phase 2)
Escherichia coli Infections (Phase 4)
Esophageal Diseases (Phase 4)
Extracorporeal Membrane Oxygenation (Phase 2)
Fissure in Ano (Phase 4)
General Surgery (Phase 4)
Gynecomastia (Phase 3)
Hand Injuries (Phase 3)
Healthy Volunteers (Phase 1)
Heart Diseases (Phase 3)
Heart Failure (Phase 4)
Heart Transplantation (Phase 4)
Hypertension ()
Hypertension, Pulmonary (Phase 1)
Hypertrophy, Left Ventricular (Phase 2)
Hypotension (Phase 4)
Inflammation (Phase 1)
Intrauterine Devices (Phase 4)
Ischemic Stroke (Phase 3)
Kidney Diseases (Phase 4)
Labor, Obstetric (Phase 4)
Lung Neoplasms (Phase 2)
Menopause (Phase 2)
Microcirculation (Phase 4)
MINOCA (Phase 4)
Myocardial Infarction (Phase 4)
Myocardial Ischemia (Phase 3)
Myocardial Reperfusion Injury (Phase 3)
Osteoporosis (Phase 3)
Pain (Phase 3)
Pancreatitis (Phase 3)
Percutaneous Coronary Intervention (Phase 4)
Perfusion (Phase 4)
Peripheral Arterial Disease (Early Phase 1)
Pharmacokinetics (Phase 1)
Phlebitis (Phase 1/Phase 2)
Placenta, Retained (Phase 4)
Radial Artery (Phase 4)
Raynaud Disease (Phase 3)
Rectal Neoplasms (Phase 1)
Regional Blood Flow (Phase 4)
Renal Insufficiency (Phase 4)
Renal Insufficiency, Chronic (Phase 4)
Retina (Phase 4)
Scleroderma, Systemic (Phase 3)
Sepsis (Phase 4)
Shock (Phase 1)
Shock, Hemorrhagic (Phase 2)
Shock, Septic (Phase 3)
Small Cell Lung Carcinoma (Phase 2)
Spasm (Phase 2/Phase 3)
ST Elevation Myocardial Infarction (Phase 4)
Stroke (Phase 3)
Tendinopathy (Phase 2)
Vascular Diseases (Phase 2)
Vasodilation (Phase 3)
Vasospasm, Intracranial (Phase 4)
Version, Fetal (Phase 2/Phase 3)
Wound Healing (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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