entinostat Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

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  • Now
Entinostat, also known as SNDX-275 and MS-275, is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers.   Wikipedia

Chemistry

  • SMILES: Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2
  • InChIKey: INVTYAOGFAGBOE-UHFFFAOYSA-N
  • Mol. Mass: 376.42
  • ALogP: 3.34
  • ChEMBL Molecule:
    entinostat  
More Chemistry

Pharmacology

Alternative names

carbamic acid, n-((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3- pyridinylmethyl ester | entinostat | ms 27-275 | ms-27-275 | ms 275 | ms-275 | n-(2-aminophenyl)-4-(n-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide | sndx-275

Organizations (47)

Research & Development (47)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (75)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (75)


 

Anemia, Refractory (Phase 2)

Brain Neoplasms (Phase 1)

Brain Stem Neoplasms (Phase 1)

Breast Diseases (Phase 1)

Breast Neoplasms (Phase 3)

Breast Neoplasms, Male (Phase 2)

Bronchial Neoplasms (Phase 1)

Burkitt Lymphoma (Phase 1)

Carcinoma, Non-Small-Cell Lung (Phase 2)

Carcinoma, Ovarian Epithelial (Phase 1/Phase 2)

Carcinoma, Renal Cell (Phase 2)

Cholangiocarcinoma (Phase 2)

Colonic Neoplasms (Phase 2)

Colorectal Neoplasms (Phase 2)

Digestive System Neoplasms (Phase 1)

Drug Interactions (Phase 1)

Endocrine Gland Neoplasms (Phase 1)

Endometrial Neoplasms (Phase 2)

Epigenetic Repression (Phase 2)

Fallopian Tube Neoplasms (Phase 2)

Glioma (Phase 1)

Hamartoma (Phase 2)

Healthy Volunteers (Phase 1)

Hodgkin Disease (Phase 2)

Intraocular Lymphoma (Phase 1)

Kidney Failure, Chronic (Phase 1)

Kidney Neoplasms (Phase 2)

Leukemia (Phase 1)

Leukemia, Eosinophilic, Acute (Phase 1)

Leukemia, Lymphocytic, Chronic, B-Cell (Phase 1)

Leukemia-Lymphoma, Adult T-Cell (Phase 1)

Leukemia, Monocytic, Acute (Phase 2)

Leukemia, Myelogenous, Chronic, BCR-ABL Positive (Phase 2)

Leukemia, Myeloid, Acute (Phase 2)

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative (Phase 1)

Leukemia, Myeloid, Chronic-Phase (Phase 1)

Leukemia, Myelomonocytic, Acute (Phase 2)

Leukemia, Myelomonocytic, Chronic (Phase 2)

Lung Diseases (Phase 1)

Lung Neoplasms (Phase 1)

Lymphoma (Phase 2)

Lymphoma, B-Cell, Marginal Zone (Phase 1)

Lymphoma, Follicular (Phase 1)

Lymphoma, Large B-Cell, Diffuse (Phase 1)

Lymphoma, Large-Cell, Anaplastic (Phase 1)

Lymphoma, Large-Cell, Immunoblastic (Phase 1)

Lymphoma, Mantle-Cell (Phase 1)

Lymphoma, Non-Hodgkin (Phase 2)

Lymphoma, Primary Cutaneous Anaplastic Large Cell (Phase 1)

Lymphoma, T-Cell (Phase 1)

Lymphomatoid Granulomatosis (Phase 1)

Melanoma (Phase 2)

Multiple Myeloma (Phase 1)

Myelodysplastic-Myeloproliferative Diseases (Phase 1)

Myelodysplastic Syndromes (Phase 2)

Myeloproliferative Disorders (Phase 2)

Neoplasm Metastasis (Phase 2)

Neoplasms (Phase 2)

Neoplasms by Histologic Type (Phase 1)

Neoplasms, Glandular and Epithelial (Phase 1)

Neuroendocrine Tumors (Phase 2)

Ovarian Diseases (Phase 2)

Ovarian Neoplasms (Phase 2)

Pancreatic Neoplasms (Phase 2)

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Phase 2)

Prostatic Neoplasms (Phase 1)

Respiratory Tract Neoplasms (Phase 1)

Sezary Syndrome (Phase 1)

Small Cell Lung Carcinoma (Phase 1)

Thoracic Neoplasms (Phase 1)

Thrombocytopenia (Phase 2)

Triple Negative Breast Neoplasms (Phase 2)

Urinary Bladder Neoplasms (Phase 2)

Volunteers (Phase 1)

Waldenstrom Macroglobulinemia (Phase 1)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 70
  • # of Trial Organizations: 47

Trials by Phase

Trial Phase Start Date Organizations Indications

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