Active Ingredient History

  • Now
Econazole (commonly used as the nitrate salt) is an antifungal medication of the imidazole class. It is a broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally. Sold under the brand name Ecoza among others, it is indicated for the treatment of interdigital tinea pedis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum in patients 12 years of age and older. Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.   NCATS

  • SMILES: Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
  • Mol. Mass: 381.69
  • ALogP: 5.8
  • ChEMBL Molecules:
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Drug Pricing (per unit)

United States

$0.1963 - $0.4198
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole | econazole | (+-)-econazole | econazole nitrate | ecostatin | ecostatin-1 | ecostatin twin pack | gyno-pevaryl | gyno-pevaryl 150 | gyno-pevaryl 1 cp pack | gyno-pevaryl once | micofugal | pevaryl | r-14827 | spectazole | sq-13050


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