Active Ingredient History

  • Now
Salmeterol is a long-acting beta2-adrenergic agonist. Although beta2-adrenoceptors are the predominant adrenergic receptors in bronchial smooth muscle and beta1-adrenoceptors are the predominant receptors in the heart, there are also beta2-adrenoceptors in the human heart comprising 10% to 50% of the total beta-adrenoceptors. The precise function of these is not yet established, but they raise the possibility that even highly selective beta2-agonists may have cardiac effects. It is FDA approved for the treatment of asthma, prevention of exercise-induced bronchospasm, maintenance treatment of chronic obstructive pulmonary disease. Common adverse reactions include musculoskeletal pain, headache, influenza, nasal/sinus congestion, pharyngitis, rhinitis, tracheitis/bronchitis, cough, throat irritation, viral respiratory infection. Salmeterol should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, because the action of salmeterol on the vascular system may be potentiated by these agents. Coadministration of salmeterol and ketoconazole was associated with more frequent increases in QTc duration compared with salmeterol and placebo administration.   NCATS

  • SMILES: OCc1cc(ccc1O)C(O)CNCCCCCCOCCCCc2ccccc2
  • Mol. Mass: 415.57
  • ALogP: 4.11
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Topical
  • Pro Drug: No

Drug Pricing (per unit)

United States

$4.7345 - $7.3243


More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( fluticasone (cutivate), salmeterol (serevent) - other names: advair hfa, airduo digihaler, airduo respiclick, fluticasone propionate/salmeterol (fs), wixela inhub )
beglan | budesonide / salmeterol | cryogenine | cryogenine, (10alpha)-isomer | gr-33343 g | gr-33343-g | gr-33343x | gr-33343-x | neovent | salmaterol | salmeterol | salmeterol / fluticasone propionate | salmeterolum | salmeterol xinafoate | salmeterol xinafoate / fluticasone propionate | serevent | soltel | vertine


Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue