Active Ingredient History

  • Now
Dolasetron is an antinauseant and antiemetic agent, which is approved as a mesylate salt under the brand name anzement for the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy, including initial and repeat courses; and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is thought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small intestine, and that the released serotonin then activates 5-HT3 receptors located on vagal efferents to initiate the vomiting reflex. This drug is not shown to have activity at other known serotonin receptors, and has low affinity for dopamine receptors. Dolasetron mesilate is rapidly reduced by carbonyl reductase to form its major pharmacologically active metabolite reduced dolasetron. In addition dolasetron was in the phase III clinical trials for the investigation, that intravenous using of dolasetron mesilate reduces pain intensity in patients with fibromyalgia.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral
  • Pro Drug: No
1h-indole-3-carboxylic acid, (6r,9as)-octahydro-3-oxo-2,6-methano-2h-quinolizin-8-yl ester, rel-, methanesulfonate, hydrate (1:1:1) | 1h-indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2h-quinolizin-8-yl ester, (2-alpha,6-alpha,8-alpha,9a-beta)- | 1h-indole-3-carboxylic acid-trans-octahydro-3-oxo-2,6-methano-2h-quinolizin-8-yl ester methanesulfonate | anemet | anzemet | anzemet hydrate | azasetron | azasetron hcl | azasetron hydrochloride | dolasetron | dolasétron | dolasetron mesilate | dolasetron mesilate monohydrate | dolasetron mesylate | dolasetron mesylate hydrate | dolasetron mesylate monohydrate | dolasetron methanesulfonate hydrate | dolasetronum | indole-3-carboxylic acid, ester with (8r)-hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one | mdl 73147ef | mdl 73,147ef | mdl-73147ef | nazasetron | octahydro-3-oxo-2,6-methano-2h-quinolizin-8-yl 1h-indole-3-carboxylate | sens-401


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