Active Ingredient History

  • Now
Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in the blood producing highly unpleasant symptoms. Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase, which acts in the second step of ethanol utilization. In addition, disulfiram competitively binds and inhibits the peripheral benzodiazepine receptor, which may indicate some value in the treatment of the symptoms of alcohol withdrawal, however this activity has not been extensively studied. Used for the treatment and management of chronic alcoholism.   NCATS

  • Mol. Mass: 296.539
  • ALogP: 3.62
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$1.0101 - $1.7719
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

1,1'-dithiobis(n,n-diethylthioformamide) | antabuse | antabuse (tn) | bis(diethylthiocarbamoyl) disulfide | disulfiram | esperal | n,n,n',n'-tetraethylthiuram disulfide | nsc-25953 | tetraethylthioperoxydicarbonic diamide | tetraethylthiram disulfide | tetraethylthiuram disulfide | tetraethylthiuram disulphide


Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue