Active Ingredient History
Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage adrenal insufficiency and is used in the form of betamethasone benzoate, betamethasone dipropionate, or betamethasone valerate for the treatment of inflammation due to corticosteroid-responsive dermatoses. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.Betamethasone is used for: treating certain conditions associated with decreased adrenal gland function. It is used to treat severe inflammation caused by certain conditions, including severe asthma, severe allergies, rheumatoid arthritis, ulcerative colitis, certain blood disorders, lupus, multiple sclerosis, and certain eye and skin conditions. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Adrenal Hyperplasia, Congenital (approved 1961)
Asthma (approved 1961)
Colitis, Ulcerative (approved 1961)
Lymphoma (approved 1961)
Multiple Sclerosis (approved 1961)
Rhinitis, Allergic (approved 1961)
Achilles Tendon (Phase 2)
Adrenal Insufficiency (Phase 4)
Alopecia Areata (Phase 4)
Amyotrophic Lateral Sclerosis (Early Phase 1)
Ankle Injuries (Phase 2)
Arthritis (Phase 1/Phase 2)
Arthritis, Rheumatoid (Phase 4)
Arthrocentesis (Phase 4)
Back Pain (Phase 4)
Botulinum Toxins, Type A (Phase 1)
Bronchiolitis (Phase 2/Phase 3)
Bursitis (Phase 4)
Carcinoma, Non-Small-Cell Lung (Phase 2)
Carpal Tunnel Syndrome (Phase 4)
Child (Phase 2/Phase 3)
Choroidal Neovascularization (Phase 1)
Chronic Pain (Phase 4)
Cicatrix, Hypertrophic (Phase 3)
Colorectal Neoplasms (Phase 2)
Community-Acquired Infections (Phase 3)
Corneal Diseases (Phase 1/Phase 2)
Coronary Artery Disease (Phase 4)
Cough (Phase 3)
Crohn Disease (Phase 4)
Cyclosteroids (Phase 1)
Cystic Adenomatoid Malformation of Lung, Congenital (Phase 1/Phase 2)
Delivery, Obstetric (Phase 4)
De Quervain Disease (Phase 4)
Dermatitis, Atopic (Phase 4)
Dermatitis, Contact (Phase 3)
Dermatitis, Photoallergic (Phase 1)
Dermatitis, Phototoxic (Phase 1)
Dermatitis, Seborrheic (Phase 3)
Diabetes Mellitus (Phase 2)
Dry Eye Syndromes (Phase 2)
Eczema (Phase 4)
Elbow (Phase 1/Phase 2)
Facial Injuries (Phase 3)
Fasciitis, Plantar (Phase 1)
Glaucoma, Open-Angle (Phase 2)
Glomerulonephritis, IGA (Phase 4)
Graft Rejection (Phase 2)
Granulomatous Mastitis (Phase 4)
Headache (Phase 4)
Healthy Volunteers (Phase 1)
Hemorrhage (Phase 4)
Hyperopia (Phase 1/Phase 2)
Hypersensitivity (Phase 3)
Hypoglycemia (Phase 4)
Hypoparathyroidism (Phase 4)
Hypospadias (Early Phase 1)
Infant, Premature (Phase 2)
Infant, Premature, Diseases (Phase 4)
Inflammatory Bowel Diseases (Phase 4)
Keloid (Phase 3)
Kidney Transplantation (Phase 4)
Lichen Planus, Oral (Phase 4)
Liver Diseases (Phase 2)
Liver Transplantation (Phase 2)
Low Back Pain (Phase 4)
Lumbar Vertebrae (Phase 4)
Lupus Nephritis (Phase 3)
Macular Degeneration (Phase 1)
Macular Edema (Phase 2/Phase 3)
Mandibular Diseases (Phase 4)
Melanoma (Phase 2)
Migraine Disorders (Phase 4)
Myopia (Phase 1/Phase 2)
Neck Pain (Phase 4)
Neonatology (Phase 4)
Neoplastic Cells, Circulating (Phase 2)
Nephrotic Syndrome (Phase 3)
Neurodermatitis (Phase 3)
Obstetric Labor Complications (Phase 3)
Obstetric Labor, Premature (Phase 4)
Oral Submucous Fibrosis (Phase 3)
Orbital Pseudotumor (Phase 3)
Osteoarthritis (Phase 4)
Osteoarthritis, Knee (Phase 4)
Otitis Media (Phase 3)
Pain (Phase 4)
Pain, Postoperative (Phase 4)
Pelvic Girdle Pain (Phase 2)
Periarthritis (Phase 3)
Pharyngitis (Phase 3)
Phimosis (Phase 4)
Popliteal Cyst (Phase 3)
Postoperative Nausea and Vomiting (Phase 4)
Pregnancy (Phase 3)
Pregnancy Complications (Phase 4)
Pregnancy Outcome (Phase 3)
Premature Birth (Phase 4)
Prostatitis (Early Phase 1)
Pruritus (Phase 2)
Psoriasis ()
Pterygium (Phase 1/Phase 2)
Radiculopathy (Phase 4)
Respiratory Distress Syndrome (Phase 4)
Respiratory Distress Syndrome, Newborn (Phase 2/Phase 3)
Rhinitis (Phase 4)
Rhinitis, Allergic (Phase 3)
Rotator Cuff Injuries (Phase 2)
Sciatic Neuropathy (Phase 2)
Shock, Septic (Phase 4)
Shoulder Impingement Syndrome (Phase 4)
Shoulder Pain (Phase 4)
Skin and Connective Tissue Diseases (Phase 2)
Skin Diseases, Eczematous (Phase 4)
Spinal Stenosis (Phase 4)
Sprains and Strains (Phase 2)
Stomatitis, Aphthous (Phase 2)
Tendinopathy (Phase 4)
Tennis Elbow (Phase 3)
Tinea (Phase 3)
Tonsillectomy (Phase 4)
Transient Tachypnea of the Newborn (Phase 2)
Trigger Finger Disorder (Phase 4)
Vasoconstriction (Phase 1)
Vestibular Diseases (Phase 4)
Vestibular Neuronitis (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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