eflornithine (ornidyl) Report issue

Small molecule Orphan Drug FDA Approved FDA Priority Review FDA

Active Ingredient History

  • Now
Eflornithine is a prescription drug indicated in the treatment of facial hirsutism (excessive hair growth). Eflornithine hydrochloride cream for topical application is intended for use in women suffering from facial hirsutism and is sold by Allergan, Inc. under the brand name Vaniqa. Besides being a non-mechanical and non-cosmetic treatment, eflornithine is the only non-hormonal and non-systemic prescription option available for women who suffer from facial hirsutism. Eflornithine for injection against sleeping sickness was manufactured by Sanofi Aventis and sold under the brand name Ornidyl in the USA. It is now discontinued. Eflornithine is on the World Health Organization's List of Essential Medicines. Eflornithine prevents hair growth by inhibiting the anagen phase of hair production. This occurs by eflornithine irreversibly binding (also called suicide inhibition) to ornithine decarboxylase (ODC) and physically preventing the natural substrate ornithine from accessing the active site.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral, Topical
  • Pro Drug: No

Drug Pricing (per unit)

More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

2-(difluoromethyl)ornithine | alpha-(difluoromethyl)-dl-ornithine | alpha-difluoromethylornithine | dfmo | dfmo hcl | difluoromethylornithine | difluromethylornithine | eflornithine | eflornithine hcl | eflornithine hdyrochloride | eflornithine hydrochloride | eflornithine hydrochloride anhydrous | eflornithine hydrochloride hydrate | eflornithine hydrochloride monohydrate | elfornithine | mdl-71782a | ornidyl | (rs)-2,5-diamino-2-(difluoromethyl)pentanoic acid | vaniqa | α-difluoromethylornithine


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