clozapine (clozaril) Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Clozapine was discovered in 1958 by an anesthetist and now it is used for the treatment of schizophrenia. Although the exact mechanism of its action is unknown, the effect of clozapine on schizophrenia is associated with inhibition of dopamine D2 and serotonin 2A receptors.   NCATS

Chemistry

  • SMILES: CN1CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C24
  • InChIKey: QZUDBNBUXVUHMW-UHFFFAOYSA-N
  • Mol. Mass: 326.823
  • ALogP: 3.72
  • ChEMBL Molecule:
    clozapine  
More Chemistry

Pharmacology

Drug Pricing (per unit)

United States

$0.1638 - $90.4525

Australia

$0.2506 - $104.6655
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

asaleptin | azaleptine | clozapin | clozapina | clozapine | clozapinum | clozaril | fazaclo | fazaclo odt | hf-1854 | klozapol | leponex | lu af35700 | zaponex

Organizations (96)

Research & Development (83)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (13)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (21)

Approved Indications (2)


 

Psychotic Disorders

Schizophrenia

Experimental Indications - Clinical Trial Phases 1-4 (21)


 

Alcoholism (Phase 4)

Anxiety Disorders (Phase 3)

Bipolar Disorder (Phase 4)

Dementia (Phase 3)

Depression (Phase 3)

Developmental Disabilities (Phase 3)

Diagnosis, Dual (Psychiatry) (Phase 4)

Healthy Volunteers (Phase 1)

Intellectual Disability (Phase 3)

Liver Diseases (Phase 1)

Marijuana Abuse (Phase 4)

Metabolic Syndrome (Phase 4)

Panic Disorder (Phase 4)

Pharmacology (Phase 1)

Psychophysiologic Disorders (Phase 3)

Psychotic Disorders (Phase 4)

Renal Insufficiency (Phase 1)

Schizophrenia ()

Schizophrenia, Childhood (Phase 4)

Schizophrenia, Treatment-Resistant (Phase 4)

Substance-Related Disorders (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 70
  • # of Trial Organizations: 83

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue