clofarabine (clolar) Report issue

Small molecule Orphan Drug FDA Approved FDA Fast Track FDA Accelerated Approval FDA Priority Review FDA

Active Ingredient History

  • Now
Clofarabine is a anti-cancer drug which was approved by FDA for the treatment of pediatric patients with relapsed or refractory acute lymphoblastic leukemia. After crossing the cell membrane the drug is rapidly metabolized by deoxycytidine kinase to diphosphate and triphosphate metabolites and these metabolites reversibly inhibit hRNR by binding to alpha subunit. Also the triphosphate is incorporated to DNA where it acts as a chain terminator.   NCATS

  • SMILES: NC1=NC(Cl)=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3F
  • Mol. Mass: 303.677
  • ALogP: -0.35
  • ChEMBL Molecule:
More Chemistry

Drug Pricing (per unit)

United States

$23.1560 - $557.3900
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

2-chloro-2'-arabino-fluoro-2'-deoxyadenosine | 2-chloro-2'-fluoroarabino-2'-deoxyadenosine | 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine | 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine | 2-chloro-9-(2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl)adenine | 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arbinofuranosyl)adenine | (2r,3r,4s,5r)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol | cafda | cl-f-ara-a | clofarabin | clofarabina | clofarabine | clofarabinum | clofarex | clolar | cloloar | evoltra


Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue