Active Ingredient History

  • Now
Cilengitide is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis, and other aspects of tumor biology. Hence, it is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation.   Wikipedia

  • SMILES: CC(C)[C@@H]1N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC1=O
  • Mol. Mass: 588.67
  • ALogP: -2.18
  • ChEMBL Molecule:
More Chemistry
cilengitide | cyclic-arg-gly-asp-d-phe(n-methyl)val | cyclo(arginyl-glycyl-formylaspartyl-n-methylvalyl) | cyclo(rgdf-n(me)v) | emd-12192 | emd121974 | emd 121974 | emd-121974


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