Active Ingredient History

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Polmacoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It was developed as CG100649 and approved for use in South Korea in February 2015. It inhibits the enzymes carbonic anhydrase and COX-2. A study in healthy volunteers showed drug effects on urinary prostaglandin metabolites for both polmacoxib and celecoxib that suggest a similar cardiovascular risk profile. Further work by this group developed dose-exposure relationships of polmacoxib to guide clinical development strategies.   Wikipedia

  • SMILES: CC1(C)OC(=C(C1=O)c2cccc(F)c2)c3ccc(cc3)S(=O)(=O)N
  • Mol. Mass: 361.39
  • ALogP: 2.72
  • ChEMBL Molecule:
More Chemistry
cg100649 | polmacoxib


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