irinotecan (Camptosar) Report issue

Small molecule Approved FDA Accelerated Approval FDA Priority Review FDA

Active Ingredient History

  • Now
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Irinotecan is sold under the brand name Camptosar among others. CAMPTOSAR is a topoisomerase inhibitor indicated for: • First-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic carcinoma of the colon or rectum. • Patients with metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following initial fluorouracil-based therapy. Irinotecan is a derivative of camptothecin. Camptothecins interact specifically with the enzyme topoisomerase I, which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of irinotecan is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either irinotecan or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: Yes

Drug Pricing (per unit)

United States

$1.5820 - $189.6680


$2.5197 - $31.4539
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

7-ethyl-10-hydroxycamptothecin | bax2398 | biotecan | campto | camptosar | camptothecin-11 | camptothecine | (+)-camptothecine | cpt 11 | cpt-11 | d-camptothecin | ezn-2208 | folfiri | folfirinox | irinotecan | irinotecan hcl | irinotecan hydrochloride | irinotecan hydrochloride hydrate | irinotecan hydrochloride trihydrate | irinotecan liposome | irinotecan liposome injection | irinotecan sucrosofate | irrinotecan | liposomal cpt-11 | liposomal irinotecan | mm-398 | nanoliposomal irinotecan | nk012 compound | onivyde | pep02 | pep-02 | pep02 compound | (s)-camptothecin | (s)-(+)-camptothecin | sn 38 | sn-38 | sn 38 11 | sn-38-11 | sn38 cpd | u-101440e


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