Active Ingredient History

  • Now
Florbetaben F18 is a18F-labeled stilbene derivative used as a tracer for PET imaging of beta-amyloid deposits in the human brain. The F 18 isotope produces a positron signal that is detected by a PET scanner. 3H-florbetaben in vitro binding experiments reveal two binding sites (Kd of 16 nM and 135 nM) in frontal cortex homogenates from patients with AD. Binding of florbetaben F18 to beta-amyloid plaques in post-mortem brain sections from patients with AD using autoradiography correlates with both immunohistochemical and Bielschowsky silver stains. Florbetaben F 18 does not bind to tau or alpha-synuclein in tissue from patients with AD. Neither Neuraceq nor non-radioactive florbetaben F 19 bind to AT8 positive tau deposits in brain tissue from patients with frontotemporal dementia (FTD), using autoradiography and immunohistochemistry, respectively.   NCATS

  • SMILES: CNc1ccc(\C=C\c2ccc(OCCOCCOCCF)cc2)cc1
  • Mol. Mass: 359.44
  • ALogP: 4.28
  • ChEMBL Molecules:
More Chemistry
  • Mechanisms of Action: Missing data
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No
18f-bay94-9172 | [18f]florbetaben | 18f-florbetaben | 4-(n-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene | bay 94-9172 | bay-949172 | bay94 9172 | bay94-9172 | florbetaben | florbetaben (18f) | florbetaben f18 | florbetaben f-18 | florbetaben f18 injection | neuraceq | unii-tla7312toi


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