Active Ingredient History
Lacticaseibacillus rhamnosus is a bacterium that originally was considered to be a subspecies of L. casei, but genetic research found it to be a separate species in the L. casei clade, which also includes L. paracasei and L. zeae. It is a short Gram-positive homofermentative facultative anaerobic non-spore-forming rod that often appears in chains. Some strains of L. rhamnosus bacteria are being used as probiotics, and are particularly useful in treating infections of the female urogenital tract, most particularly very difficult to treat cases of bacterial vaginosis. The species Lacticaseibacillus rhamnosus and Limosilactobacillus reuteri are commonly found in the healthy female genito-urinary tract and are helpful to regain control of dysbiotic bacterial overgrowth during an active infection. L. rhamnosus sometimes is used in dairy products such as fermented milk and as non-starter-lactic acid bacterium (NSLAB) in long-ripened cheese. While frequently considered a beneficial organism, L. rhamnosus may not be as beneficial to certain subsets of the population; in rare circumstances, especially those primarily involving weakened immune system or infants, it may cause endocarditis. Despite the rare infections caused by L. rhamnosus, the species is included in the list of bacterial species with qualified presumed safety (QPS) status of the European Food Safety Agency. Wikipedia
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abdominal Pain (Phase 2)
Aged (Phase 1)
Anxiety (Phase 2)
Asthma (Phase 4)
Atypical Squamous Cells of the Cervix (Phase 2)
Autism Spectrum Disorder (Phase 1/Phase 2)
Bacteriuria (Phase 1)
Bronchopulmonary Dysplasia (Phase 3)
Burns (Phase 2)
Candidiasis, Vulvovaginal (Phase 1)
Chronic Periodontitis (Phase 2)
Clostridioides difficile (Phase 4)
Clostridium Infections (Early Phase 1)
Colitis, Ulcerative (Phase 2)
Colonic Neoplasms (Phase 4)
Colonoscopy (Phase 2)
Colorectal Neoplasms (Phase 2)
Conjunctivitis, Allergic (Phase 2/Phase 3)
Cross Infection (Phase 3)
Cystic Fibrosis (Phase 3)
Death (Phase 4)
Dermatitis, Atopic (Phase 4)
Diabetes Mellitus, Type 1 (Phase 4)
Diabetes Mellitus, Type 2 (Phase 2)
Diarrhea (Phase 4)
Digestive System Neoplasms (Phase 4)
Drug Resistance, Bacterial (Phase 2)
Dyspepsia (Phase 1/Phase 2)
Enterocolitis (Phase 4)
Enterocolitis, Pseudomembranous (Phase 4)
Febrile Neutropenia (Phase 2)
Feces (Phase 4)
Gastroenteritis (Phase 3)
Gastroesophageal Reflux (Phase 4)
Gastrointestinal Microbiome (Phase 3)
Gastrointestinal Neoplasms (Phase 1/Phase 2)
Glucose Intolerance (Phase 3)
Healthy Volunteers (Phase 3)
Helicobacter pylori (Phase 4)
Hepatic Encephalopathy (Phase 1)
HIV (Phase 1/Phase 2)
HIV Infections (Phase 2/Phase 3)
Hospitalization (Phase 2)
Infant, Low Birth Weight (Phase 2/Phase 3)
Infections (Phase 4)
Infertility, Female (Phase 4)
Inflammation (Phase 2)
Influenza, Human (Phase 4)
Intensive Care Units (Phase 2)
Intestinal Neoplasms (Phase 4)
Irritable Bowel Syndrome (Phase 3)
Leukomalacia, Periventricular (Phase 3)
Live Birth (Phase 3)
Liver Diseases, Alcoholic (Phase 4)
Lower Urinary Tract Symptoms (Phase 2)
Mania (Phase 2)
Metabolic Syndrome (Phase 4)
Milk Hypersensitivity (Phase 2/Phase 3)
Neoplasms (Phase 3)
Neutropenia (Phase 2)
Obesity (Phase 1/Phase 2)
Pneumonia (Phase 4)
Pneumonia, Ventilator-Associated (Phase 4)
Poliovirus Vaccine, Oral (Phase 4)
Pregnancy (Phase 3)
Premature Birth (Phase 3)
Probiotics (Phase 1)
Prostheses and Implants (Phase 4)
Respiratory Tract Infections (Phase 4)
Rhinitis, Allergic (Phase 3)
Rotavirus Infections (Phase 4)
Sepsis (Phase 3)
Signs and Symptoms, Digestive (Phase 1/Phase 2)
Sinusitis (Phase 4)
Spinal Cord Injuries (Phase 3)
Stress Disorders, Post-Traumatic (Phase 2)
Urinary Bladder, Neurogenic (Phase 3)
Urinary Tract Infections (Phase 2)
Vaginal Diseases (Phase 4)
Vaginosis, Bacterial (Phase 4)
Ventilators, Mechanical (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
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