Active Ingredient History

  • Now
Calcifediol (25-Hydroxyvitamin D3 or 25-hydroxycholecalciferol) is a biologically active vitamin D3 metabolite. It is concluded that the liver is the major if not the only physiologic site of hydroxylation of vitamin D3 into calcifediol. Calcifediol is a prohormone of the active form of vitamin D3, calcitriol (1,25-dihydroxyvitamin D3). Calcifediol is converted to calcitriol by cytochrome P450 27B1 (CYP27B1), also called 1-alpha hydroxylase, primarily in the kidney. Calcitriol binds to the vitamin D receptor in target tissues and activates vitamin D responsive pathways that result in increased intestinal absorption of calcium and phosphorus and reduced parathyroid hormone synthesis. RAYALDEE (calcifediol) extended-release capsules is indicated for the treatment of secondary hyperparathyroidism in adult patients with stage 3 or 4 chronic kidney disease.   NCATS

  • SMILES: C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(=C\C=C/3\C[C@@H](O)CCC3=C)\CCC[C@]12C
  • Mol. Mass: 400.65
  • ALogP: 6.73
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$22.2793 - $36.6193
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

25-hydroxycholecalciferol | 25-hydroxy vitamin d | 25-hydroxy vitamin d3 | 25-hydroxyvitamin d3 | (3s,5z,7e)-9,10-secocholesta-5,7,10-triene-3,25-diol | (3β,5z,7e)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol | (5z,7e)-(3s)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol | calcidiol | calcifediol | calcifédiol | calcifediol anhydrous | calcifediolum | calcifidiol | calderol | u-32070e


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