Active Ingredient History
Tocopherol (alpha tocopheryl nicotinate) is an ester of tocopherol and nicotinic acid. Vitamin E (Tocopherol) is sold commercially as the esterified form (alpha tocopheryl acetate, alpha tocopheryl succinate and alpha tocopheryl nicotinate). Alpha tocopheryl nicotinate has antioxidant and vasodilatory properties. It can be used as a mild warming agent, without producing the redness typical for nicotinic acid. Tocopherol (alpha tocopheryl nicotinate) has been available in Japan since 1967. Tocopherol under the brand name Juvela N is approved in Japan for the treatment of symptoms accompanying hypertension, hyperlipidemia, peripheral circulatory disturbance resulting from arteriosclerosis obliterans. Tocopherol has being shown to inhibit platelet aggregation. NCATS
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Arteriosclerosis Obliterans (approved 1966)
Hyperlipidemias (approved 1966)
Hypertension (approved 1966)
CADASIL (Phase 2)
Coronavirus Infections (Phase 3)
COVID-19 (Phase 3)
Deficiency Diseases (Phase 2)
Diabetes Mellitus (Phase 4)
Diabetic Retinopathy (Phase 3)
Infant, Premature (Phase 4)
Lymphedema (Phase 4)
Obesity (Phase 4)
Ophthalmology (Phase 4)
Oxidative Stress (Phase 2)
Pregnancy Complications (Phase 2)
Squamous Cell Carcinoma of Head and Neck (Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
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