Active Ingredient History
Dexamethasone acetate (NEOFORDEX®) is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), it reduces the immune response. Dexamethasone acetate (NEOFORDEX®) is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products. Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regulation of nuclear factor-κB activity and an activation of caspase-9 through second mitochondria-derived activator of caspase (Smac; an apoptosis promoting factor) release. Prolonged exposure was required to achieve maximum levels of apoptotic markers along with increased caspase-3 activation and DNA fragmentation. Dexamethasone also down-regulated anti apoptotic genes and increased IκB-alpha protein levels. Dexamethasone apoptotic activity is enhanced by the combination with thalidomide or its analogues and with proteasome inhibitor (e.g. bortezomib). NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Conjunctivitis, Bacterial (approved 1962)
Corneal Injuries (approved 1962)
Keratitis, Herpetic (approved 1962)
Multiple Myeloma (approved 2016)
Rosacea (approved 1962)
Uveitis, Intermediate (approved 1962)
Acne Vulgaris (Phase 1/Phase 2)
Acute Pain (Phase 4)
Addison Disease (Phase 4)
Adrenal Cortex Hormones (Phase 4)
Adrenal Hyperplasia, Congenital (Phase 4)
Altitude Sickness (Phase 1)
Ambulatory Surgical Procedures (Phase 4)
Amyloid (Phase 2)
Amyloidosis (Phase 2)
Analgesia (Phase 4)
Analgesics (Phase 4)
Analgesics, Opioid (Phase 4)
Anaphylaxis (Phase 1)
Anaplasia (Phase 2)
Androgens (Phase 2)
Anemia, Sickle Cell (Early Phase 1)
Anesthesia (Phase 4)
Anesthesia and Analgesia (Phase 4)
Anesthesia, Conduction (Phase 3)
Anesthesia, Epidural (Phase 4)
Anesthesia, General (Phase 3)
Anesthesia, Local (Phase 4)
Anesthesia, Spinal (Phase 2)
Anosmia (Phase 4)
Anterior Cruciate Ligament Injuries (Phase 4)
Anterior Temporal Lobectomy (Phase 4)
Antigens, CD20 (Phase 2)
Aphasia (Phase 3)
Arthropathy, Neurogenic (Phase 4)
Arthroplasty (Phase 4)
Arthroplasty, Replacement, Knee (Phase 4)
Arthroplasty, Replacement, Shoulder (Phase 4)
Asthma ()
Ataxia Telangiectasia (Phase 3)
Back Pain (Phase 3)
beta-Thalassemia (Early Phase 1)
Bile Duct Neoplasms (Phase 2)
Blood Protein Disorders (Phase 2)
Brachial Plexus Block (Phase 4)
Brain Edema (Phase 3)
Brain Injuries, Traumatic (Phase 3)
Brain Neoplasms (Phase 2)
Breast Neoplasms (Phase 4)
Bronchiolitis (Phase 3)
Bronchiolitis, Viral (Phase 4)
Burkitt Lymphoma (Phase 2)
Burning Mouth Syndrome (Phase 4)
Carcinoma (Phase 3)
Carcinoma, Non-Small-Cell Lung (Phase 3)
Carcinoma, Transitional Cell (Phase 3)
Castleman Disease (Phase 2)
Cataract (Phase 4)
Central Serous Chorioretinopathy (Phase 1)
Cerebrospinal Fluid Otorrhea (Phase 4)
Cesarean Section (Phase 3)
Child (Phase 4)
Cholangiocarcinoma (Phase 2)
Cholecystectomy, Laparoscopic (Phase 3)
Cholesterol (Early Phase 1)
Chromosome Disorders (Phase 2)
Chronic Pain (Phase 4)
Cisplatin (Phase 2)
Cleft Lip (Phase 4)
Clonal Hematopoiesis (Phase 2)
Cluster Headache (Phase 1)
Cochlear Implants (Phase 3)
Collagen (Phase 4)
Colorectal Neoplasms (Phase 4)
Colorectal Surgery (Phase 3)
Conjunctivitis (Phase 4)
Conjunctivitis, Allergic (Phase 3)
Conjunctivitis, Bacterial (Phase 3)
Corneal Diseases (Phase 4)
Corneal Edema (Phase 4)
Corneal Endothelial Cell Loss (Phase 4)
Coronaviridae Infections (Phase 2)
Coronavirus Infections (Phase 4)
COVID-19 (Phase 4)
Crohn Disease (Phase 4)
Croup (Phase 4)
Cyclin D1 (Phase 2)
Cyclophosphamide (Phase 2)
Cyclosteroids (Phase 1)
Deglutition Disorders (Phase 4)
Depression (Phase 4)
Dexamethasone (Phase 4)
Dexmedetomidine (Phase 4)
Diabetes Mellitus (Phase 4)
Diabetic Retinopathy (Phase 4)
Digestive System Diseases (Phase 4)
Down Syndrome (Phase 3)
Drug Evaluation (Phase 4)
Drug Misuse (Phase 4)
Drugs, Investigational (Phase 4)
Dry Eye Syndromes (Phase 4)
Dyslipidemias (Phase 3)
Dysphonia (Phase 3)
Dyspnea (Phase 3)
Edema (Phase 4)
Emergence Delirium (Phase 1)
Encephalitis, Viral (Phase 4)
Endothelium (Phase 4)
Enteral Nutrition (Phase 4)
Enterocolitis, Necrotizing (Phase 4)
Ependymoma (Phase 2)
Epiretinal Membrane (Phase 4)
Esophageal Neoplasms (Phase 2)
Eye Diseases (Phase 3)
Eye Diseases, Hereditary (Phase 4)
Femoral Neck Fractures (Phase 4)
Fentanyl (Phase 2/Phase 3)
Fetal Development (Phase 3)
Foot Diseases (Phase 2)
Fractures, Bone (Phase 4)
Gastrointestinal Diseases (Phase 4)
Gastrointestinal Neoplasms (Phase 4)
General Surgery (Phase 4)
Genetic Diseases, Inborn (Phase 2)
Genital Neoplasms, Female (Phase 3)
Glaucoma (Phase 4)
Glaucoma, Open-Angle (Phase 4)
Glomerulonephritis (Phase 3)
Graft vs Host Disease (Phase 4)
Hamartoma (Phase 2)
Hand Injuries (Phase 4)
Headache (Phase 1)
Head and Neck Neoplasms (Phase 4)
Healthy Volunteers (Phase 1/Phase 2)
Hearing Loss (Phase 1/Phase 2)
Hearing Loss, Noise-Induced (Phase 1/Phase 2)
Hearing Loss, Sensorineural (Phase 4)
Hearing Loss, Sudden (Phase 1/Phase 2)
Hematologic Diseases (Phase 2)
Hematologic Neoplasms (Phase 4)
Hematopoietic Stem Cell Transplantation (Phase 4)
Hip Dislocation (Phase 2/Phase 3)
Hip Injuries (Phase 3)
Histiocytosis, Langerhans-Cell (Phase 2)
Histiocytosis, Sinus (Phase 2)
Histone Deacetylase Inhibitors (Phase 2)
HIV Infections (Phase 2)
Hoarseness (Phase 4)
Hodgkin Disease (Phase 3)
Hyaline Membrane Disease (Phase 4)
Hyperlipidemias (Phase 1)
Hypersensitivity (Phase 3)
Hypertension (Phase 3)
Hypocalcemia (Phase 4)
Hypoparathyroidism (Phase 4)
Hypospadias (Phase 4)
Hypotension (Phase 4)
Hypoxia (Phase 3)
Immune System Diseases (Phase 2)
Immunoglobulin Light-chain Amyloidosis (Phase 3)
Immunoproliferative Disorders (Phase 2)
Immunotherapy (Phase 1/Phase 2)
Infections (Phase 4)
Inflammation (Phase 4)
Inflammatory Bowel Diseases (Phase 4)
Inosine Triphosphate (Phase 2)
Intensive Care Units (Phase 3)
Intervertebral Disc Displacement (Phase 4)
Intestinal Diseases (Phase 4)
Intestinal Neoplasms (Phase 4)
Keloid (Phase 4)
Keratoconus (Phase 4)
Keratoplasty, Penetrating (Phase 4)
Ketamine (Phase 3)
Kidney Calculi (Phase 4)
Kidney Failure, Chronic (Phase 3)
Labor, Obstetric (Phase 1)
Laparoscopy (Phase 4)
Leg Injuries (Phase 4)
Leiomyoma (Phase 3)
Lens Diseases (Phase 3)
Leukemia (Phase 3)
Leukemia, Hairy Cell (Phase 1)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 1/Phase 2)
Leukemia, Lymphoid (Phase 1)
Leukemia-Lymphoma, Adult T-Cell (Phase 1/Phase 2)
Leukemia, Myeloid, Acute (Phase 3)
Leukemia, Myeloid, Chronic-Phase (Phase 1/Phase 2)
Leukemia, Myelomonocytic, Chronic (Phase 1/Phase 2)
Leukemia, T-Cell (Phase 2/Phase 3)
Lichen Planus, Oral (Phase 2)
Lidocaine (Phase 3)
Liver (Phase 1)
Lumbar Vertebrae (Phase 4)
Lung Neoplasms (Phase 4)
Lymphatic Diseases (Phase 2)
Lymphohistiocytosis, Hemophagocytic (Phase 4)
Lymphoma (Phase 4)
Lymphoma, B-Cell (Phase 2)
Lymphoma, Extranodal NK-T-Cell (Phase 2)
Lymphoma, Follicular (Phase 1/Phase 2)
Lymphoma, Large B-Cell, Diffuse (Phase 2/Phase 3)
Lymphoma, Large-Cell, Anaplastic (Phase 3)
Lymphoma, Large-Cell, Immunoblastic (Phase 3)
Lymphoma, Mantle-Cell (Phase 2)
Lymphoma, Non-Hodgkin (Phase 3)
Lymphoma, T-Cell (Phase 4)
Lymphoma, T-Cell, Cutaneous (Phase 1)
Lymphoma, T-Cell, Peripheral (Phase 1)
Lymphoproliferative Disorders (Phase 2)
Macular Degeneration (Phase 4)
Macular Edema (Phase 4)
Mammaplasty (Phase 2)
Mandibular Diseases (Phase 4)
Mastectomy, Modified Radical (Phase 4)
Mastocytosis, Systemic (Phase 1)
Mastodynia (Phase 4)
Mastoiditis (Phase 3)
Medulloblastoma (Phase 2)
Meibomian Gland Dysfunction (Phase 4)
Melanoma (Phase 2)
Membranes (Phase 2)
Meniere Disease (Phase 3)
Migraine Disorders (Phase 4)
Migraine with Aura (Phase 1/Phase 2)
Molar, Third (Phase 4)
Morphine (Phase 4)
Multiple Myeloma (Phase 4)
Mutation (Phase 2)
Myelodysplastic Syndromes (Phase 1/Phase 2)
Nasopharyngeal Carcinoma (Phase 1)
Nausea (Phase 4)
Neoadjuvant Therapy (Phase 2)
Neoplasm Metastasis (Phase 2/Phase 3)
Neoplasms (Phase 4)
Neoplasms by Histologic Type (Phase 2)
Neoplasms, Germ Cell and Embryonal (Phase 2)
Neoplasms, Plasma Cell (Phase 2)
Nerve Block (Phase 4)
Neuralgia (Phase 4)
Neuralgia, Postherpetic (Phase 4)
Neuritis (Phase 4)
Neurodegenerative Diseases (Phase 1)
Nidovirales Infections (Phase 2)
Olfaction Disorders (Phase 4)
Ophthalmology (Phase 4)
Oral Health (Phase 4)
Oral Surgical Procedures (Phase 3)
Oropharyngeal Neoplasms (Phase 3)
Orthopedic Procedures (Phase 4)
Osteoarthritis (Phase 4)
Osteoarthritis, Hip (Phase 4)
Osteoarthritis, Knee (Phase 4)
Otitis Media with Effusion (Phase 4)
Ovarian Neoplasms (Phase 2)
Pain (Phase 4)
Pain Management (Phase 4)
Pain, Postoperative (Phase 4)
Pancreatic Neoplasms (Phase 4)
Panuveitis (Phase 4)
Papilledema (Phase 4)
Paraproteinemias (Phase 2)
Patient Preference (Phase 4)
Pemphigus (Phase 2)
Pericarditis (Phase 4)
Peripheral Arterial Disease (Phase 2)
Peripheral Nervous System Agents (Phase 4)
Pharmacokinetics (Phase 4)
Pharmacology (Phase 3)
Pharyngitis (Phase 2/Phase 3)
Physiology (Phase 4)
Plasmablastic Lymphoma (Phase 2)
Plasmacytoma (Phase 2)
Pneumonia (Phase 3)
Pneumonia, Viral (Phase 3)
Postoperative Complications (Phase 4)
Postoperative Nausea and Vomiting (Phase 4)
Post-Traumatic Headache (Phase 4)
Pregnancy (Phase 3)
Premature Birth (Phase 4)
Prostatic Hyperplasia (Phase 4)
Prostatic Neoplasms (Phase 3)
Prosthesis-Related Infections (Phase 2)
Psoriasis (Phase 4)
Pterygium (Phase 4)
Purpura, Thrombocytopenic, Idiopathic (Phase 4)
Purpura, Thrombotic Thrombocytopenic (Phase 2)
Pyelonephritis (Phase 3)
Quality of Life (Phase 4)
Radiculopathy (Phase 4)
Radiofrequency Ablation (Phase 4)
Recurrence (Phase 2)
Refractive Surgical Procedures (Phase 4)
Renal Insufficiency (Phase 2)
Respiratory Distress Syndrome (Phase 3)
Respiratory Insufficiency (Phase 4)
Respiratory Syncytial Virus Infections (Phase 1)
Respiratory Tract Diseases (Phase 2)
Respiratory Tract Infections (Phase 2)
Retinal Detachment (Phase 4)
Retinal Diseases (Phase 4)
Retinal Vein Occlusion (Phase 4)
Retroperitoneal Fibrosis (Phase 2/Phase 3)
Rituximab (Phase 2)
RNA Virus Infections (Phase 2)
Ropivacaine (Phase 4)
Rosacea (Phase 4)
Rotator Cuff Injuries (Phase 4)
Safety (Phase 4)
SARS-CoV-2 (Phase 2/Phase 3)
Sciatica (Phase 3)
Sciatic Neuropathy (Phase 4)
Sepsis (Phase 4)
Severe Acute Respiratory Syndrome (Phase 4)
Shivering (Phase 4)
Shoulder Impingement Syndrome (Phase 4)
Shoulder Injuries (Phase 4)
Shoulder Pain (Phase 4)
Skin Diseases (Early Phase 1)
Sleep Apnea, Obstructive (Phase 2)
Sleep Disorders, Intrinsic (Early Phase 1)
Small Cell Lung Carcinoma (Phase 3)
Smoldering Multiple Myeloma (Phase 2)
Spinal Cord Injuries (Phase 2)
Spinal Fusion (Phase 3)
Spinal Injuries (Phase 3)
Spinal Stenosis (Phase 4)
Spondylosis (Phase 4)
Stomach Diseases (Phase 1)
Stomach Neoplasms (Phase 2)
Stomatitis (Phase 2)
Strabismus (Phase 3)
Stroke (Phase 1)
Subarachnoid Hemorrhage (Phase 3)
Surgery, Oral (Phase 4)
Systemic Inflammatory Response Syndrome (Phase 4)
Temporomandibular Joint Disorders (Phase 4)
Tendinopathy (Phase 4)
Testicular Neoplasms (Phase 3)
Thoracic Surgery (Phase 3)
Thrombocytopenia (Phase 3)
Thrombosis (Phase 2)
Time (Phase 4)
Tinnitus (Phase 4)
Tonsillectomy (Phase 3)
Tonsillitis (Phase 4)
Tooth Abnormalities (Phase 4)
Toxoplasmosis, Cerebral (Phase 2)
Translocation, Genetic (Phase 1/Phase 2)
Treatment Outcome (Phase 4)
Trigeminal Neuralgia (Phase 1)
Trigger Finger Disorder (Phase 4)
Triple Negative Breast Neoplasms (Phase 1/Phase 2)
Tuberculosis, Meningeal (Phase 2)
Upper Extremity (Phase 4)
Ureteral Neoplasms (Phase 3)
Urethral Stricture (Phase 4)
Urinary Bladder Neoplasms (Phase 3)
Urinary Tract Infections (Phase 3)
Uterine Prolapse (Phase 2)
Uveitis (Phase 4)
Uveitis, Anterior (Phase 2)
Uveitis, Intermediate (Phase 4)
Uveitis, Posterior (Phase 4)
Venous Thrombosis (Phase 2)
Virus Diseases (Phase 2)
Viscum (Phase 4)
Vitamin D Deficiency (Phase 4)
Vitiligo (Phase 1)
Vitrectomy (Phase 4)
Vitreoretinal Surgery (Phase 4)
Vitreous Body (Phase 1)
Vomiting (Phase 2)
Waldenstrom Macroglobulinemia (Phase 2/Phase 3)
Wet Macular Degeneration (Phase 2)
Wounds and Injuries (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).
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