Active Ingredient History

  • Now
Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. Animal studies have suggested antianxiety activity and the absence of abuse potential. Behavioural, electrophysiological and receptor binding experiments gradually led to the idea that buspirone owes much of its anxiolytic activity to its ability to attenuate central 5-hydroxytryptamine neurotransmission. In vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HT1A) receptors. Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. The drug was approved by FDA for the treatment of anxiety.   NCATS

  • SMILES: O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4
  • Mol. Mass: 385.51
  • ALogP: 2.09
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0134 - $0.9415


$0.4256 - $0.6810
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

8-(4-(4-(2-pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione | buspar | buspin | buspiron | buspirona | buspirone | buspirone hcl | buspirone hydrochloride | buspironum | mj-9022-1


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