epothilone Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Epothilones are a class of potential cancer drugs. Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials, epothilones have better efficacy and milder adverse effects than taxanes.   Wikipedia

Chemistry

  • SMILES: C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)\C(=C\c3csc(C)n3)\C
  • InChIKey: QXRSDHAAWVKZLJ-PVYNADRNSA-N
  • Mol. Mass: 507.69
  • ALogP: 4.48
  • ChEMBL Molecule:
    patupilone  
More Chemistry

Pharmacology

Alternative names

12,13-desoxyepothilone b | depob cpd | desoxyepothilone b | epo906 | epo b | epothilon b | epothilon d | epothilone | (−)-epothilone b | epothilone b | epothilone b, desoxy | epothilone d | epothiolone d | gnf-pf-193 | kos862 | kos 862 | kos-862 | patupilone | utd1

Organizations (19)

Research & Development (19)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (20)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (20)


 

Breast Neoplasms (Phase 3)

Carcinoid Tumor (Phase 2)

Carcinoma, Hepatocellular (Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 2)

Central Nervous System Neoplasms (Phase 1)

Colonic Neoplasms (Phase 2)

Colorectal Neoplasms (Phase 2)

Fallopian Tube Neoplasms (Phase 3)

Glioblastoma (Phase 1/Phase 2)

Head and Neck Neoplasms (Phase 1)

Kidney Neoplasms (Phase 2)

Lung Neoplasms (Phase 2)

Lymphoma (Phase 1)

Melanoma (Phase 2)

Neoplasm Metastasis (Phase 2)

Neoplasms (Phase 2)

Neuroendocrine Tumors (Phase 2)

Ovarian Neoplasms (Phase 3)

Peritoneal Neoplasms (Phase 3)

Prostatic Neoplasms (Phase 2)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 38
  • # of Trial Organizations: 19

Trials by Phase

Trial Phase Start Date Organizations Indications

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