Active Ingredient History
Colistimethate is a methanesulfonate of polymyxin antibacterial colistin. Colistimethate is a nonactive prodrug. In aqueous solutions, colistimethate is hydrolyzed and forms a complex mixture of partially sulfomethylated derivatives and colistin. The antimicrobial activity of colistin is similar to that of polymyxin B and is restricted to gram-negative bacteria, including P aeruginosa, Acinetobacter species, Enterobacter-Klebsiella tribe, Escherichia coli, Salmonella and Shigella species, Citrobacter species, Yersinia pseudotuberculosis, Morganella morganii and Haemophilus influenzae. Colistin has also been shown to possess considerable in vitro activity against Stenotrophomonas maltophilia. Colistin and polymyxin B, however, do not have activity against Proteus, Providencia, Serratia species, Pseudomonas mallei, Burkholderia cepacia, Brucella species, most gram-positive bacteria, gram-negative cocci, anaerobes, fungi and parasites. Parenteral or nebulized colistimethate is indicated for the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli. It is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Abdominal Injuries (Phase 3)
Acinetobacter baumannii (Phase 3)
Bacteremia (Phase 3)
Bacterial Infections (Phase 3)
Blood-Borne Infections (Phase 3)
Bronchiectasis (Phase 4)
Bronchitis (Phase 3)
Colistin (Phase 4)
Colorectal Neoplasms (Phase 4)
Communicable Diseases (Phase 4)
Critical Illness (Phase 4)
Cross Infection (Phase 4)
Cystic Fibrosis (Phase 4)
Drug Resistance, Bacterial (Phase 4)
Drugs, Investigational (Phase 3)
Gram-Negative Bacteria (Phase 1)
Gram-Negative Bacterial Infections (Phase 4)
Healthcare-Associated Pneumonia (Phase 3)
Healthy Volunteers (Phase 1)
Infections (Phase 4)
Intestinal Neoplasms (Phase 2)
Klebsiella pneumoniae (Phase 4)
Lymphoma (Phase 4)
Neoplasms (Phase 2/Phase 3)
Pneumococcal Infections (Phase 1)
Pneumonia (Phase 3)
Pneumonia, Bacterial (Phase 3)
Pneumonia, Ventilator-Associated (Phase 4)
Pseudomonas aeruginosa (Phase 2)
Pseudomonas Infections (Phase 1)
Pyelonephritis (Phase 3)
Sepsis (Phase 3)
Shock, Septic (Phase 3)
Urinary Tract Infections (Phase 3)
Trial | Phase | Start Date | Organizations | Indications |
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