Active Ingredient History

  • Now
Gonadorelin is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use. Gonadorelin is used for the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Parenteral
  • Pro Drug: No
abbott-41070 | ay-24031 | cystorelin | factrel | fertagyl | fertiral lh-rh | gnrh | gnrh-i | gonadoliberin i | gonadorelin | gonadorelina | gonadorelin acetate | gonadorelin decapeptide | gonadorelin diacetate | gonadoréline | gonadorelin hcl | gonadorelin hydrochloride | gonadorelinum | gonadotropin releasing hormone | gonadotropin-releasing hormone | human gonadoliberin-i | hypocrine | lh releasing factor | luteinizing hormone-releasing factor diacetate tetrahydrate | luteinizing hormone-releasing factor dihydrochloride | luteinizing hormone-releasing factor (swine) | luteinizing hormone releasing hormone | lutrelef | lutrepulse | lutrepulse kit | relefact lh-rh


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