Active Ingredient History
Paritaprevir is a potent inhibitor of the NS3/4A protease that rapidly and consistently suppresses HCV. Paritaprevir is metabolized by the Cytochrome P450 isoform 3A (CYP3A); therefore, ritonavir was used concurrently to increase plasma concentrations and to prolong the half-life of this agent allowing for once-daily dosing. Several antiviral regimens combining paritaprevir with other agents have shown impressive results, tolerable side effects, and importantly, provided support of ‘all-oral’ interferon-free regimens against HCV. Paritaprevir monotherapy is discontinued now but paritaprevir is used as a component of Viekira Pak and Technivie for the treatment of patients with genotype 1 chronic hepatitis C virus (HCV) infection. NCATS
Combination drugs
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Hepatitis C, Chronic (approved 2015)
Fibrosis (Phase 3)
Genotype (Phase 3)
Healthy Volunteers (Phase 1)
Hepacivirus (Phase 4)
Hepatitis B (Phase 2/Phase 3)
Hepatitis C (Phase 4)
Hepatitis C, Chronic (Phase 4)
Hepatitis Viruses (Phase 4)
HIV (Phase 3)
HIV Infections (Phase 2)
Kidney Diseases (Phase 3)
Kidney Failure, Chronic (Phase 4)
Liver Cirrhosis (Phase 3)
Pharmacology (Phase 1)
Renal Insufficiency, Chronic (Phase 4)
Trial | Phase | Start Date | Organizations | Indications |
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