Active Ingredient History

  • Now
Trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid (also known as Fluciclovine (18F)) was approved under brand name AXUMIN as a radioactive diagnostic agent indicated for positron emission tomography (PET) imaging in men with suspected prostate cancer recurrence. Besides, this radioactive compound is used in patients with cervical, ovarian epithelial or endometrial cancers. Fluciclovine F 18 is a synthetic amino acid transported across mammalian cell membranes by amino acid transporters, such as LAT-1 and ASCT2, which are upregulated in prostate cancer cells, but as was shown, this compound has a higher affinity for ASCT2 in comparison with other transporters.   NCATS

  • SMILES: C[C@@]1(F)C[C@@](N)(C1)C(=O)O
  • Mol. Mass: 147.15
  • ALogP: 0.29
  • ChEMBL Molecules:
More Chemistry
  • Mechanisms of Action: Missing data
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No
18f | (18f)facbc | 18f facbc | 18f-facbc | 18f-fluciclovine | (18f)ge-148 | 1-amino-3-fluorocyclobutane-1-carboxylic acid | (1r,3r)-1-amino-3(18f)fluorocyclobutane-1-carboxylic acid | anti-(18f)facbc | anti-1-amino-3-(18f)fluorocyclobutane-1-carboxylic acid | axumin | cyclobutanecarboxylic acid, 1-amino-3-(fluoro-18f)-, trans- | f(18)1-amino-3-fluorocyclobutane-1-carboxylic acid | f(18)-facbc | facbc | facbc f-18 | f-facbc | fluciclovine | fluciclovine (18f) | fluciclovine f18 | fluciclovine f 18 | fluciclovine f-18 | ge-148 (18f) | ge-148 f-18 | nmk36 | nmk 36 | nmk-36 | nmk36 cpd


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